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Malignant pleural mesothelioma: single-institution experience of 101 patients over a 15-year period

Background: Malignant pleural mesothelioma (MPM) is a rare but aggressive neoplasm that typically originates from the mesothelial surfaces of the pleural cavity. Exposure to asbestos is the principal etiological agent of MPM. The disease is characterized by difficult stage classification and limited...

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Published in:Acta chirurgica belgica 2017-05, Vol.117 (3), p.157-163
Main Authors: Domen, Andreas, De Laet, Christophe, Vanderbruggen, Wies, Gielis, Jan, Hendriks, Jeroen M. H., Lauwers, Patrick, Janssens, Annelies, Hiddinga, Birgitta, Van Meerbeeck, Jan P., Van Schil, Paul E.
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Language:English
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Summary:Background: Malignant pleural mesothelioma (MPM) is a rare but aggressive neoplasm that typically originates from the mesothelial surfaces of the pleural cavity. Exposure to asbestos is the principal etiological agent of MPM. The disease is characterized by difficult stage classification and limited consensus on therapeutic approach. We have evaluated the experience with MPM in the Antwerp University Hospital over the past 15 years. Methods: A database was created with all patients diagnosed with or treated for a MPM between 2001 and 2015. A total of 101 patients were included on which different survival analyses were performed combined with a reproduction of demographic, clinical, histologic and therapeutic data, and these were compared to literature data. Results: Vast majority of our 101 patients were male (80%) with a median age of 66 years at diagnosis with predominantly epitheloid histology (81%). Overall median survival was 18.3 months and overall 1-, 2- and 5-year survival rates were 68%, 37% and 7%, respectively. Kaplan-Meier analysis showed a non-significant difference in survival between the several best (b) TNM-stages (p = .356). A significant difference in survival was observed in patients undergoing surgery versus no surgery (p = .008), between the different histological types (p 
ISSN:0001-5458
DOI:10.1080/00015458.2016.1272253