Species Identification and Resistance Status of Anopheles gambiae s.l. (Diptera: Culicidae) Mosquitoes in Guinea

Insecticide resistance is one of the primary threats to the recent gains in malaria control. This is especially true in Guinea, where long-lasting insecticidal nets are currently the primary vector control intervention. To better inform the national malaria control program on the current status of i...

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Bibliographic Details
Published in:Journal of medical entomology 2017-05, Vol.54 (3), p.677-681
Main Authors: Keita, K., Camara, D., Barry, Y., Ossè, R., Wang, L., Sylla, M., Miller, D., Leite, L., Schopp, P., Lawrence, G. G., Akogbéto, M., Dotson, E. M., Guilavogui, T., Keita, M., Irish, S. R.
Format: Article
Language:English
Subjects:
Ace1 R
Animals
Anopheles - genetics
Anopheles - physiology
Anopheles coluzzii
Anopheles gambiae
Aquatic insects
Bioassays
Control methods
Culicidae
Deltamethrin
Female
Genetic Markers
Guinea
Insect Proteins - genetics
Insect Proteins - metabolism
Insecticide Resistance
Insecticides
Insecticides - pharmacology
kdr
Malaria
Mosquito Control
Mosquitoes
Mutation
Pesticide resistance
Pyrethroids
VECTOR CONTROL, PEST MANAGEMENT, RESISTANCE, REPELLENTS
Vector-borne diseases
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Summary:Insecticide resistance is one of the primary threats to the recent gains in malaria control. This is especially true in Guinea, where long-lasting insecticidal nets are currently the primary vector control intervention. To better inform the national malaria control program on the current status of insecticide resistance in Guinea, resistance bioassays were conducted, using Anopheles gambiae s.l. Giles, in three sites. Molecular analyses were also done on An. gambiae s.l. to determine the species and find whether the target-site mutations kdr and Ace1R were present. Susceptibility tests revealed resistance to DDT and pyrethroids, although mosquitoes were susceptible to deltamethrin in two of the three sites tested. Mosquitoes were susceptible to bendiocarb, except in Kissidougou, Guinea. The kdr-west mutation was widespread and the frequency was 60% or more in all sites. However, the Ace1R mutation was present in low levels. Insecticide susceptibility should continue to be monitored in Guinea to ensure insecticide-based vector control methods remain effective.
ISSN:0022-2585
1938-2928
DOI:10.1093/jme/tjw228