Longitudinal changes in quality of life following ICD implant and the impact of age, gender, and ICD shocks: observations from the INTRINSIC RV trial

Purpose ICDs can improve survival in at-risk patients but no consensus exists with respect to their impact on health-related quality of life (QOL). Moreover, the data are unclear on QOL benefits in specific patient subgroups. We sought to analyze, in the INTRINSIC RV ICD trial population, health-rel...

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Bibliographic Details
Published in:Journal of interventional cardiac electrophysiology 2017-04, Vol.48 (3), p.291-298
Main Authors: Gopinathannair, Rakesh, Lerew, Darin R., Cross, Natalie J., Sears, Samuel F., Brown, Scott, Olshansky, Brian
Format: Article
Language:English
Subjects:
Adult
Age Distribution
Aged
Aged, 80 and over
Cardiology
Defibrillators, Implantable - psychology
Defibrillators, Implantable - statistics & numerical data
Electric Injuries - epidemiology
Electric Injuries - prevention & control
Electric Injuries - psychology
Female
Health Care Surveys
Heart Failure - diagnosis
Heart Failure - prevention & control
Heart Failure - psychology
Humans
Longitudinal Studies
Male
Medicine
Medicine & Public Health
Middle Aged
Patient Satisfaction - statistics & numerical data
Prevalence
Quality of Life - psychology
Sex Distribution
Survival Rate
Treatment Outcome
United States - epidemiology
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Summary:Purpose ICDs can improve survival in at-risk patients but no consensus exists with respect to their impact on health-related quality of life (QOL). Moreover, the data are unclear on QOL benefits in specific patient subgroups. We sought to analyze, in the INTRINSIC RV ICD trial population, health-related QOL longitudinally following ICD implant and consider impact of age, gender, and ICD shocks on QOL by employing a global measure of health-related QOL. Methods One thousand five hundred thirty patients had an ICD implanted. One week after implant ( n  = 1461), 988 patients were randomized to DDDR with AV search hysteresis ( n  = 502) or VVI ( n  = 486) programming. QOL data, using the SF-36 short form, were obtained for the 1461 patient cohort, irrespective of randomization status, at baseline and prospectively for 1 year following ICD implant. Results Longitudinal mixed-effect analyses revealed significant improvements from baseline across all SF-36 subscales and component scores for the overall study cohort. Women had a substantially lower QOL at baseline, although their improvement after implant was similar to men. Patients
ISSN:1383-875X
1572-8595
DOI:10.1007/s10840-017-0233-y