Impact Of Diabetes Mellitus On Ischemic Events In Men And Women After Percutaneous Coronary Intervention

Abstract Studies have shown worse outcome for women compared with men after percutaneous coronary intervention (PCI), especially in the presence of diabetes mellitus (DM). We aimed to investigate the risk of ischemic events after PCI in women versus men stratified by the presence or absence of DM. A...

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Published in:The American journal of cardiology 2017-04, Vol.119 (8), p.1166-1172
Main Authors: Farhan, Serdar, MD, Baber, Usman, MD, MS, Vogel, Birgit, MD, Aquino, Melissa, MS, Chandrasekhar, Jaya, MBBS, Faggioni, Michela, MD, Giustino, Gennaro, MD, Kautzky-Willer, Alexandra, MD, Sweeny, Joesph, MD, Shah, Srushti, MD, Vijay, Pooja, MD, Barman, Nitin, MD, Moreno, Pedro, MD, Kovacic, Jason, MD, PhD, Dangas, George, MD, PhD, Kini, Annapoorna, MD, Mehran, Roxana, MD, Sharma, Samin, MD
Format: Article
Language:English
Subjects:
Aged
Angioplasty
C-Reactive Protein - analysis
Cardiovascular
Cardiovascular disease
Coronary Artery Disease - mortality
Coronary Artery Disease - therapy
Death
Diabetes mellitus
Diabetes Mellitus - epidemiology
Female
Follow-Up Studies
Glycated Hemoglobin A - analysis
Health risk assessment
Humans
Intervention
Ischemia
Male
Men
Middle Aged
Mortality
Multivariate Analysis
Myocardial infarction
Myocardial Infarction - epidemiology
New York - epidemiology
Percutaneous Coronary Intervention
Registries
Retrospective Studies
Risk
Risk Assessment
Sex Factors
Stents
Womens health
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cited_by cdi_FETCH-LOGICAL-c481t-85416e5e45f6b0f532f54c0e070c1669a8e793d08825d30937e3ec782d68ab9d3
cites cdi_FETCH-LOGICAL-c481t-85416e5e45f6b0f532f54c0e070c1669a8e793d08825d30937e3ec782d68ab9d3
container_end_page 1172
container_issue 8
container_start_page 1166
container_title The American journal of cardiology
container_volume 119
creator Farhan, Serdar, MD
Baber, Usman, MD, MS
Vogel, Birgit, MD
Aquino, Melissa, MS
Chandrasekhar, Jaya, MBBS
Faggioni, Michela, MD
Giustino, Gennaro, MD
Kautzky-Willer, Alexandra, MD
Sweeny, Joesph, MD
Shah, Srushti, MD
Vijay, Pooja, MD
Barman, Nitin, MD
Moreno, Pedro, MD
Kovacic, Jason, MD, PhD
Dangas, George, MD, PhD
Kini, Annapoorna, MD
Mehran, Roxana, MD
Sharma, Samin, MD
description Abstract Studies have shown worse outcome for women compared with men after percutaneous coronary intervention (PCI), especially in the presence of diabetes mellitus (DM). We aimed to investigate the risk of ischemic events after PCI in women versus men stratified by the presence or absence of DM. A total of 17,154 consecutive patients from a single center PCI registry enrolled between January 2009 and December 2014 were categorized accordingly: female/non-DM, female/DM, male/non-DM and male/DM. Endpoints included death and myocardial infarction (MI) at 1 year. Of the overall population, 15% (n=2631) were female/non-DM, 17% (n=2891) were female/DM, 38% (n=6483) were male/non-DM and 30% (n=5149) were male/DM. Within the four study groups, female/DM had the highest risk, while female/non-DM and male/DM showed similar risks and male/non-DM showed lowest risk for death (4.64% vs. 3.08% vs. 2.93% vs. 2.31%; p-trend
doi_str_mv 10.1016/j.amjcard.2016.12.035
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We aimed to investigate the risk of ischemic events after PCI in women versus men stratified by the presence or absence of DM. A total of 17,154 consecutive patients from a single center PCI registry enrolled between January 2009 and December 2014 were categorized accordingly: female/non-DM, female/DM, male/non-DM and male/DM. Endpoints included death and myocardial infarction (MI) at 1 year. Of the overall population, 15% (n=2631) were female/non-DM, 17% (n=2891) were female/DM, 38% (n=6483) were male/non-DM and 30% (n=5149) were male/DM. Within the four study groups, female/DM had the highest risk, while female/non-DM and male/DM showed similar risks and male/non-DM showed lowest risk for death (4.64% vs. 3.08% vs. 2.93% vs. 2.31%; p-trend&lt;0.0001 over all groups and p=0.69 between female/non-DM and male/DM, respectively) and MI (4.15% vs. 3.99% vs. 3.71% vs. 2.55%; p-trend&lt;0.0001 over all groups and p=0.97 between female/non-DM and male/DM, respectively). After multivariate adjustment findings were largely unchanged suggesting highest risk for adverse events in diabetic women compared to other groups and comparable risks for death and MI in non-diabetic women compared with diabetic men. In conclusion, these findings highlight the combined influence of DM and female sex as strong determinants of post-PCI risk while also illustrating “risk equivalence” between non-diabetic women vs. diabetic men.</description><identifier>ISSN: 0002-9149</identifier><identifier>EISSN: 1879-1913</identifier><identifier>DOI: 10.1016/j.amjcard.2016.12.035</identifier><identifier>PMID: 28236457</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Aged ; Angioplasty ; C-Reactive Protein - analysis ; Cardiovascular ; Cardiovascular disease ; Coronary Artery Disease - mortality ; Coronary Artery Disease - therapy ; Death ; Diabetes mellitus ; Diabetes Mellitus - epidemiology ; Female ; Follow-Up Studies ; Glycated Hemoglobin A - analysis ; Health risk assessment ; Humans ; Intervention ; Ischemia ; Male ; Men ; Middle Aged ; Mortality ; Multivariate Analysis ; Myocardial infarction ; Myocardial Infarction - epidemiology ; New York - epidemiology ; Percutaneous Coronary Intervention ; Registries ; Retrospective Studies ; Risk ; Risk Assessment ; Sex Factors ; Stents ; Womens health</subject><ispartof>The American journal of cardiology, 2017-04, Vol.119 (8), p.1166-1172</ispartof><rights>2017</rights><rights>Copyright © 2017. 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We aimed to investigate the risk of ischemic events after PCI in women versus men stratified by the presence or absence of DM. A total of 17,154 consecutive patients from a single center PCI registry enrolled between January 2009 and December 2014 were categorized accordingly: female/non-DM, female/DM, male/non-DM and male/DM. Endpoints included death and myocardial infarction (MI) at 1 year. Of the overall population, 15% (n=2631) were female/non-DM, 17% (n=2891) were female/DM, 38% (n=6483) were male/non-DM and 30% (n=5149) were male/DM. Within the four study groups, female/DM had the highest risk, while female/non-DM and male/DM showed similar risks and male/non-DM showed lowest risk for death (4.64% vs. 3.08% vs. 2.93% vs. 2.31%; p-trend&lt;0.0001 over all groups and p=0.69 between female/non-DM and male/DM, respectively) and MI (4.15% vs. 3.99% vs. 3.71% vs. 2.55%; p-trend&lt;0.0001 over all groups and p=0.97 between female/non-DM and male/DM, respectively). After multivariate adjustment findings were largely unchanged suggesting highest risk for adverse events in diabetic women compared to other groups and comparable risks for death and MI in non-diabetic women compared with diabetic men. 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We aimed to investigate the risk of ischemic events after PCI in women versus men stratified by the presence or absence of DM. A total of 17,154 consecutive patients from a single center PCI registry enrolled between January 2009 and December 2014 were categorized accordingly: female/non-DM, female/DM, male/non-DM and male/DM. Endpoints included death and myocardial infarction (MI) at 1 year. Of the overall population, 15% (n=2631) were female/non-DM, 17% (n=2891) were female/DM, 38% (n=6483) were male/non-DM and 30% (n=5149) were male/DM. Within the four study groups, female/DM had the highest risk, while female/non-DM and male/DM showed similar risks and male/non-DM showed lowest risk for death (4.64% vs. 3.08% vs. 2.93% vs. 2.31%; p-trend&lt;0.0001 over all groups and p=0.69 between female/non-DM and male/DM, respectively) and MI (4.15% vs. 3.99% vs. 3.71% vs. 2.55%; p-trend&lt;0.0001 over all groups and p=0.97 between female/non-DM and male/DM, respectively). After multivariate adjustment findings were largely unchanged suggesting highest risk for adverse events in diabetic women compared to other groups and comparable risks for death and MI in non-diabetic women compared with diabetic men. In conclusion, these findings highlight the combined influence of DM and female sex as strong determinants of post-PCI risk while also illustrating “risk equivalence” between non-diabetic women vs. diabetic men.</abstract><cop>United States</cop><pub>Elsevier Inc</pub><pmid>28236457</pmid><doi>10.1016/j.amjcard.2016.12.035</doi><tpages>7</tpages></addata></record>
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identifier ISSN: 0002-9149
ispartof The American journal of cardiology, 2017-04, Vol.119 (8), p.1166-1172
issn 0002-9149
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subjects Aged
Angioplasty
C-Reactive Protein - analysis
Cardiovascular
Cardiovascular disease
Coronary Artery Disease - mortality
Coronary Artery Disease - therapy
Death
Diabetes mellitus
Diabetes Mellitus - epidemiology
Female
Follow-Up Studies
Glycated Hemoglobin A - analysis
Health risk assessment
Humans
Intervention
Ischemia
Male
Men
Middle Aged
Mortality
Multivariate Analysis
Myocardial infarction
Myocardial Infarction - epidemiology
New York - epidemiology
Percutaneous Coronary Intervention
Registries
Retrospective Studies
Risk
Risk Assessment
Sex Factors
Stents
Womens health
title Impact Of Diabetes Mellitus On Ischemic Events In Men And Women After Percutaneous Coronary Intervention
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