Base-mediated insertion reaction of alkynes into carbon-carbon σ-bonds of ethanones: synthesis of hydroxydienone and chromone derivatives

Transition-metal free insertions of alkynes into carbon-carbon σ-bonds of ethanones have been reported. These tandem reactions offer an efficient synthesis of hydroxydienones and multi-substituted chromones. This is the first example of base-promoted insertion reactions of isolated carbon-carbon tri...

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Bibliographic Details
Published in:Organic & biomolecular chemistry 2017-03, Vol.15 (12), p.2497-2500
Main Authors: Zhang, Fangfang, Yao, Qiyi, Yuan, Yang, Xu, Murong, Kong, Lingkai, Li, Yanzhong
Format: Article
Language:English
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Summary:Transition-metal free insertions of alkynes into carbon-carbon σ-bonds of ethanones have been reported. These tandem reactions offer an efficient synthesis of hydroxydienones and multi-substituted chromones. This is the first example of base-promoted insertion reactions of isolated carbon-carbon triple bonds into carbon-carbon σ-bonds with active methylene compounds bearing only one electron-withdrawing group.
ISSN:1477-0520
1477-0539
DOI:10.1039/c7ob00476a