Poly‐cytosine DNA as a High‐Affinity Ligand for Inorganic Nanomaterials

Attaching DNA to nanomaterials is the basis for DNA‐directed assembly, sensing, and drug delivery using such hybrid materials. Poly‐cytosine (poly‐C) DNA is a high affinity ligand for four types of commonly used nanomaterials, including nanocarbons (graphene oxide and single‐walled carbon nanotubes)...

Full description

Saved in:
Bibliographic Details
Published in:Angewandte Chemie International Edition 2017-05, Vol.56 (22), p.6208-6212
Main Authors: Lu, Chang, Huang, Zhicheng, Liu, Biwu, Liu, Yibo, Ying, Yibin, Liu, Juewen
Format: Article
Language:English
Subjects:
Affinity
aptamers
biosensors
Cytosine
Deoxyribonucleic acid
DNA
Drug delivery
Drug delivery systems
Hybridization
Iron oxides
Ligands
Metals
Nanomaterials
Nanoparticles
Nanotechnology
Nanotubes
Nucleotide sequence
Oxides
Pollutants
poly-cytocene
Proteins
Single wall carbon nanotubes
Surfactants
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Attaching DNA to nanomaterials is the basis for DNA‐directed assembly, sensing, and drug delivery using such hybrid materials. Poly‐cytosine (poly‐C) DNA is a high affinity ligand for four types of commonly used nanomaterials, including nanocarbons (graphene oxide and single‐walled carbon nanotubes), transition metal dichalcogenides (MoS2 and WS2), metal oxides (Fe3O4 and ZnO), and metal nanoparticles (Au and Ag). Compared to other homo‐DNA sequences, poly‐C DNA has the highest affinity for the first three types of materials. Using a diblock DNA containing a poly‐C block to attach to surfaces, the target DNA was successfully hybridized to the other block on graphene oxide more efficiently than that containing a typical poly‐A block, especially in the presence of non‐specific background DNA, proteins, or surfactants. This work provides a simple solution for functionalizing nanomaterials with non‐modified DNA and offers new insights into DNA biointerfaces. Straight‐C student: Poly‐cytosine (poly‐C) DNA adsorbs tighter than other DNA homopolymers (such as poly‐A) on nanocarbons, metal oxides, and transition‐metal dichalcogenides, allowing poly‐C to be used as a general anchor on these surfaces for their functionalization, especially in the presence of competing proteins, nucleic acids, and surfactants. F=fluorophore.
ISSN:1433-7851
1521-3773
DOI:10.1002/anie.201702998