Cryo-EM Structure of the Open Human Ether-à-go-go-Related K+ Channel hERG

The human ether-à-go-go-related potassium channel (hERG, Kv11.1) is a voltage-dependent channel known for its role in repolarizing the cardiac action potential. hERG alteration by mutation or pharmacological inhibition produces Long QT syndrome and the lethal cardiac arrhythmia torsade de pointes. W...

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Bibliographic Details
Published in:	Cell 2017-04, Vol.169 (3), p.422-430.e10
Main Authors:	Wang, Weiwei, MacKinnon, Roderick
Format:	Article
Language:	English
Subjects:	action potentials Amino Acid Sequence arrhythmia chemical structure cryo-electron microscopy cryo-EM Cryoelectron Microscopy drug-induced Long QT drugs ERG1 Potassium Channel - chemistry ERG1 Potassium Channel - isolation & purification ERG1 Potassium Channel - metabolism ERG1 Potassium Channel - ultrastructure hERG hERG block Humans hydrophobicity inactivation K+ channel Models, Molecular mutation potassium channels Protein Conformation Sequence Alignment structure voltage-dependent gating
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