First evidence that waterborne methylphenidate alters endocrine and behavioral stress responses in zebrafish

•Residual MPH blunted the endocrine response after acute stress.•MPH increases cortisol levels per se when the fish exposure was at environmental dose.•MPH attenuates the anxiety-like response provoked by an acute stressor in zebrafish. Several studies have reported the presence of methylphenidate (...

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Bibliographic Details
Published in:Neuroscience letters 2017-05, Vol.650, p.114-117
Main Authors: Endres, Helena Cristina, da Rosa, João Gabriel, Kabasele Kalala, Celestin, Barcellos, Heloisa Helena, Bertol, Charise Dallazem, Gil Barcellos, Leonardo José, Rossato-Grando, Luciana Grazziotin
Format: Article
Language:English
Subjects:
Animals
Behavior, Animal - drug effects
Behavior, Animal - physiology
Central Nervous System Stimulants - administration & dosage
Cortisol
Danio rerio
Dose-Response Relationship, Drug
Drug residues
Endocrine System - drug effects
Endocrine System - physiology
Environmental contamination
Female
Humans
Hydrocortisone - metabolism
Methylphenidate - administration & dosage
MPH
Stress
Stress, Physiological - drug effects
Stress, Physiological - physiology
Water Pollutants, Chemical - administration & dosage
Zebrafish - physiology
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Summary:•Residual MPH blunted the endocrine response after acute stress.•MPH increases cortisol levels per se when the fish exposure was at environmental dose.•MPH attenuates the anxiety-like response provoked by an acute stressor in zebrafish. Several studies have reported the presence of methylphenidate (MPH) in effluents; however, its impacts on aquatic life are not yet well understood. Here, we investigated the effects of acute exposure on endocrine and behavioral stress responses to environmentally relevant concentrations of MPH in zebrafish. We show that MPH blunts the response of cortisol to stress in zebrafish. On the other hand, MPH stresses fish per se. Additionally, MPH seems to modulate anxiety-like behaviors. We conclude that the presence of MPH in aquatic environments can alter neuroendocrine and behavior responses, which might considerably impact fish survival and welfare.
ISSN:0304-3940
1872-7972
DOI:10.1016/j.neulet.2017.04.039