Seroconversion rate among health care workers exposed to HIV-contaminated body fluids: The University of Pittsburgh 13-year experience

Highlights • The studies enumerating the risk of HIV transmission to health care workers as 0.3% after percutaneous exposure to HIV-positive blood, and 0.09% after a mucous membrane exposure, are weakened by outdated data which precede the introduction of highly active antiretroviral therapy (HAART)...

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Bibliographic Details
Published in:American journal of infection control 2017-08, Vol.45 (8), p.896-900
Main Authors: Nwaiwu, Chibueze A., BSN, Egro, Francesco M., MBChB, MSc, MRCS, Smith, Saundra, RN, Harper, Jay D., MD, MPH, Spiess, Alexander M., MD
Format: Article
Language:English
Subjects:
AIDS
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - therapeutic use
Body Fluids - virology
Conversion rates
Health care workers
Health Personnel
HIV
HIV Infections - transmission
HIV Seropositivity - epidemiology
Hospitals, University
Humans
Incidence
Infection Control
Infectious Disease
Infectious Disease Transmission, Patient-to-Professional
Mucocutaneous
Needlestick injuries
Occupational Exposure
Pennsylvania
Post-Exposure Prophylaxis - methods
Retrospective Studies
Seroconversion
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Summary:Highlights • The studies enumerating the risk of HIV transmission to health care workers as 0.3% after percutaneous exposure to HIV-positive blood, and 0.09% after a mucous membrane exposure, are weakened by outdated data which precede the introduction of highly active antiretroviral therapy (HAART). • A review of worldwide literature showed a lower rate of seroconversion after an occupational exposure. • Our study found a seroconversion rate of 0% after occupational exposure to HIV-contaminated body fluids, which could reflect progress over the last 20 years, since the introduction of HAART.
ISSN:0196-6553
1527-3296
DOI:10.1016/j.ajic.2017.03.012