A Dual‐Functional Persistently Luminescent Nanocomposite Enables Engineering of Mesenchymal Stem Cells for Homing and Gene Therapy of Glioblastoma

Therapeutically engineered mesenchymal stem cells (MSC) have shown promising capability for glioblastoma (GBM) therapy; however, simultaneous tracking of their migration and long‐term fate is urgently needed for clinical application. This study shows the design and fabrication of a dual‐functional p...

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Bibliographic Details
Published in:Advanced functional materials 2017-03, Vol.27 (11), p.np-n/a
Main Authors: Wu, Shu‐Qi, Yang, Cheng‐Xiong, Yan, Xiu‐Ping
Format: Article
Language:English
Subjects:
Apoptosis
Biocompatibility
Brain
cell engineering
Diagnosis
Excitation
Gene therapy
glioblastoma
Homing
Imaging
In vitro methods and tests
Luminescence
Materials science
Migration
Nanocomposites
Near infrared radiation
persistent luminescence nanocomposites
Skin & tissue grafts
Stem cells
Therapy
Toxicity
Tracking
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Summary:Therapeutically engineered mesenchymal stem cells (MSC) have shown promising capability for glioblastoma (GBM) therapy; however, simultaneous tracking of their migration and long‐term fate is urgently needed for clinical application. This study shows the design and fabrication of a dual‐functional persistent luminescence nanocomposite (LPLNP‐PPT/TRAIL) for effective therapeutic engineering and tracking of MSC in the meantime. LPLNP‐PPT/TRAIL shows low‐toxicity, near‐infrared persistent luminescence emitting without in situ excitation, and superior in vivo deep brain tissue imaging, which can efficiently track the tumortropic migration of the therapeutic engineered MSC. Both in vitro and in vivo findings demonstrate the feasibility of LPLNP‐PPT/TRAIL engineered MSC for inducing apoptosis of glioblastoma cells. This work first establishes an LPLNP‐based dual‐functional platform for cell engineering and provides us implications for GBM‐related diagnosis and therapy. A dual‐functional persistently luminescent nanocomposite (LPLNP‐PPT/TRAIL) with good biocompatibility, capable of emitting near‐infrared persistent luminescence without in situ excitation, is developed. Superior in vivo deep brain tissue imaging using this nanocomposite allows for effective therapeutic engineering and tracking of mesenchymal stem cells (MSC) in a glioblastoma (GBM) model. The engineered therapeutic and diagnostic MSC are promising for GBM‐related diagnosis and therapy.
ISSN:1616-301X
1616-3028
DOI:10.1002/adfm.201604992