Highly diastereo- and enantioselective copper-catalyzed propargylic alkylation of acyclic ketone enamines for the construction of two vicinal stereocenters

The first highly diastereo- and enantioselective propargylic alkylation of acyclic ketone enamines to form vicinal tertiary stereocenters has been reported by employing copper catalysis in combination with a bulky and structurally rigid tridentate ketimine P,N,N-ligand.

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2014-01, Vol.50 (92), p.14459-14462
Main Authors: Zhang, De-Yang, Zhu, Fu-Lin, Wang, Ya-Hui, Hu, Xin-Hu, Chen, Song, Hou, Chuan-Jin, Hu, Xiang-Ping
Format: Article
Language:English
Subjects:
Alkylation
Catalysis
Construction
Copper
Imines
Ketones
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Summary:The first highly diastereo- and enantioselective propargylic alkylation of acyclic ketone enamines to form vicinal tertiary stereocenters has been reported by employing copper catalysis in combination with a bulky and structurally rigid tridentate ketimine P,N,N-ligand.
ISSN:1359-7345
1364-548X
DOI:10.1039/c4cc06863g