Drug “Pent‐Up” in Hollow Magnetic Prussian Blue Nanoparticles for NIR‐Induced Chemo‐Photothermal Tumor Therapy with Trimodal Imaging

• Published in: Advanced healthcare materials 2017-07, Vol.6 (14), p.n/a
• Main Authors: Li, Jinghua, Zhang, Fengshou, Hu, Zhigang, Song, Weidong, Li, Guangda, Liang, Gaofeng, Zhou, Jun, Li, Ke, Cao, Yang, Luo, Zhong, Cai, Kaiyong
• Format: Article
• Language: English
• Subjects: Animals; Apoptosis; Biocompatibility; Cancer therapies; Chemotherapy; chemo‐photothermal therapy; Doxorubicin; Doxorubicin - chemistry; Doxorubicin - pharmacology; Drug delivery; Drug delivery systems; Ferrocyanides - chemistry; Ferrocyanides - pharmacology; Hep G2 Cells; hollow nanoparticles; Humans; Hyperthermia, Induced - methods; Infrared imaging; Infrared lasers; Irradiation; Lasers; Low-Level Light Therapy - methods; Magnetic resonance imaging; Magnetics; Medical imaging; Mice; Mice, Inbred ICR; Mice, Nude; Nanoparticles; Nanoparticles - chemistry; Nanoparticles - therapeutic use; Neoplasms, Experimental - metabolism; Neoplasms, Experimental - pathology; Neoplasms, Experimental - therapy; Phase change materials; phase‐change material; Photoacoustic effect; Prussian blue; Thermal imaging; Thermogenesis; Tomography; trimodal imaging; Xenograft Model Antitumor Assays
• ISSN: 2192-2640; 2192-2659; 2192-2659
• DOI: 10.1002/adhm.201700005

The study reports a biocompatible smart drug delivery system based on a doxorubicin (DOX) blending phase‐change material of 1‐pentadecanol loaded hollow magnetic Prussian blue nanoparticles, resulting in HMNP‐PB@Pent@DOX. The system possesses concentration‐dependent high thermogenesis (>50 °C) when applying a near‐infrared (NIR) laser irradiation only for 5 min. Furthermore, the system realizes near “zero release” of drug and is efficiently triggered by NIR for drug delivery in an “on” and “off” manner, thus inducing cell apoptosis in vitro and in vivo. Moreover, the system clearly indicates tumor site with trimodal imaging of magnetic resonance imaging, photoacoustic tomography imaging, and infrared thermal imaging. Furthermore, the system achieves efficient chemo‐photothermal combined tumor therapy in vivo with 808 nm laser irradiation for 5 min at 1.2 W cm−2, revealing the good tumor inhibition effect comparing with those of chemotherapy or photothermal therapy alone. The system is also confirmed to be biocompatible in regard to the mortality rate. A biocompatible, trimodal imaging guided chemo‐photothermal drug delivery system is fabricated with phase‐change material of 1‐pentadecanol filled hollow magnetic Prussian blue nanoparticles. The system realizes “on–off” and near “zero release” of drug and demonstrates great potential for synergistic tumor therapy. The study offers a promising theranostic nanoagent for chemo‐photothermal combined tumor therapy in vivo.