Novel regulation of melanogenesis by adiponectin via the AMPK/CRTC pathway

Summary Several studies observed that adiponectin, an important adipokine that improves glucose metabolism by regulating AMP‐activated protein kinase (AMPK) signaling, is dermatologically beneficial. In our recent microarray data, we found that adiponectin expression was lower in lesional skin than...

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Bibliographic Details
Published in:Pigment cell and melanoma research 2017-11, Vol.30 (6), p.553-557
Main Authors: Bang, Seunghyun, Won, Kwang Hee, Moon, Hye‐Rim, Yoo, Hanju, Hong, Areum, Song, Youngsup, Chang, Sung Eun
Format: Article
Language:English
Subjects:
Adenylate Kinase - metabolism
Adiponectin
Adiponectin - metabolism
Aminoimidazole Carboxamide - analogs & derivatives
Aminoimidazole Carboxamide - pharmacology
AMP
AMP-activated protein kinase
AMPK
Animals
antimelanogenesis
Cell Line
Cell Survival - drug effects
CREB
CRTC
Cyclic AMP response element-binding protein
DNA microarrays
Glucose
Glucose metabolism
Humans
Hyperpigmentation
Kinases
Melanin
Melanins - biosynthesis
Melanocytes
Melanosis - blood
Melanosis - pathology
Metabolism
Mice
Microphthalmia-associated transcription factor
MITF
Models, Biological
Phosphorylation
Protein turnover
Receptors, Adiponectin - metabolism
Ribonucleotides - pharmacology
Signal Transduction
Signaling
Skin diseases
Transcription factors
Transcription Factors - metabolism
Tyrosinase
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Summary:Summary Several studies observed that adiponectin, an important adipokine that improves glucose metabolism by regulating AMP‐activated protein kinase (AMPK) signaling, is dermatologically beneficial. In our recent microarray data, we found that adiponectin expression was lower in lesional skin than in non‐lesional skin of melasma patients. Given that AMPK is a key adiponectin signaling mediator, we investigated the role of adiponectin and AICAR, a cell‐permeable AMPK activator, in melanogenesis. We herein showed that adiponectin and AICAR downregulated MITF, tyrosinase, TRP‐1, and DCT expression and reduced melanin content in normal human and mouse melanocytes. The depigmenting effect of adiponectin was mediated via AMPK activation, which induced the inhibitory phosphorylation of CREB‐regulated transcription co‐activators (CRTCs) and subsequent suppression of the novel CRTC/CREB pathway in melanocytes. These findings suggest that adiponectin and its analogs are useful as a clinical strategy for treating hyperpigmentation disorders.
ISSN:1755-1471
1755-148X
DOI:10.1111/pcmr.12596