Curcumin: A Naturally Occurring Modulator of Adipokines in Diabetes

ABSTRACT Curcumin, the bioactive component of turmeric, has been used for the treatment of several diseases including diabetes and its complications. Curcumin has been shown to exert pleiotropic effects by modulating different signaling molecules, including transcription factors, chemokines, cytokin...

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Published in:Journal of cellular biochemistry 2017-12, Vol.118 (12), p.4170-4182
Main Authors: Hajavi, Jafar, Momtazi, Amir Abbas, Johnston, Thomas P., Banach, Maciej, Majeed, Muhammed, Sahebkar, Amirhossein
Format: Article
Language:English
Subjects:
ADIPOKINES
Adiponectin
Animals
BLOOD GLUCOSE
Chemokines
CURCUMIN
Curcumin - pharmacology
Curcumin - therapeutic use
Cytokines
DIABETES
Diabetes Complications - drug therapy
Diabetes Complications - metabolism
Diabetes mellitus
Diabetes Mellitus, Type 2 - drug therapy
Diabetes Mellitus, Type 2 - genetics
Female
Humans
In vivo methods and tests
Insulin
INSULIN RESISTANCE
Leptin
Male
Transcription factors
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Summary:ABSTRACT Curcumin, the bioactive component of turmeric, has been used for the treatment of several diseases including diabetes and its complications. Curcumin has been shown to exert pleiotropic effects by modulating different signaling molecules, including transcription factors, chemokines, cytokines, and adipokines. Disturbed regulation of adipokines, which include adiponectin, leptin, resistin, and visfatin, are implicated in the development of insulin resistance and Type 2 diabetes. Here, we review the findings of in vitro, in vivo, and clinical studies on the modulating effects that curcumin treatment exerts on adipokines. Additionally, we examine the potential beneficial effects of the activity of curcumin in the prevention and treatment of diabetes and its comorbidities. J. Cell. Biochem. 118: 4170–4182, 2017. © 2017 Wiley Periodicals, Inc. Here, we review the findings of in vitro, in vivo, and clinical studies on the modulating effects of curcumin treatment on adipokines, and the potential beneficial effects of this activity of curcumin in the prevention and treatment of diabetes and its comorbidities.
ISSN:0730-2312
1097-4644
DOI:10.1002/jcb.26121