Obesity, lymphadenectomy and survival outcomes in intermediate to high-risk, early-stage endometrial cancer patients

• Published in: Future oncology (London, England) England), 2015-02, Vol.11 (4), p.607-615
• Main Authors: Linkov, Faina, Edwards, Robert P, Althouse, Andrew, Rauh-Hain, Jose A, Del Carmen, Marcela G, Freese, Kyle E, Kelley, Joseph L, Olawaiye, Alexander B
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aged, 80 and over; Care and treatment; Combined Modality Therapy; Complications and side effects; Endometrial cancer; Endometrial Neoplasms - complications; Endometrial Neoplasms - mortality; Endometrial Neoplasms - pathology; Endometrial Neoplasms - surgery; Female; gynecology; Humans; Kaplan-Meier Estimate; Lymph Node Excision; lymphadenectomy; Middle Aged; Neoplasm Grading; Neoplasm Metastasis; Neoplasm Staging; Obesity; Obesity - complications; oncology; Patient outcomes; Prognosis; Retrospective Studies; survival; Treatment Outcome
• ISSN: 1479-6694; 1744-8301
• DOI: 10.2217/fon.14.247

Lymphadenectomy or lymph node dissection is a topic of controversy in endometrial cancer (EC) treatment. Associations between lymph node dissections and clinical factors were retrospectively examined in obese, endometrioid endometrial cancer patients with early-stage disease between 1995 and 2005. Overall, EC-specific and recurrence-free survival were also evaluated. Out of 192 patients, 61 (32%) did not have a lymph node examination, 55 (29%) had less than ten lymph nodes removed and 76 (39%) had ≥10 removed. Lymph node dissection count was not significantly associated with overall, EC-specific or recurrence-free survival. Analysis revealed no significant associations between ≥10 dissected lymph nodes and survival outcomes among obese, EC patients, which supports the need for additional investigation of the merit of lymphadenectomy among these patients.