Effect of silver‐loaded PMMA on Streptococcus mutans in a drip flow reactor

Orthodontic retention has been proposed as a life‐long commitment for patients who desire to maintain straight teeth. However, the presence of foreign material increases risk of bacterial colonization and caries formation, of which Streptococcus mutans is a key contributor. Multiple studies have ass...

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Published in:Journal of biomedical materials research. Part A 2017-09, Vol.105 (9), p.2632-2639
Main Authors: Williams, Dustin L., Epperson, Richard Tyler, DeGrauw, Jeffery P., Nielsen, Mattias B., Taylor, Nicholas B., Jolley, Ryan D.
Format: Article
Language:English
Subjects:
antimicrobial
Bacteria
biofilm
Biofilms
Biofilms - drug effects
Biofilms - growth & development
Bioreactors - microbiology
Colonization
Dental caries
Imaging, Three-Dimensional
Microbial Sensitivity Tests
orthodontic materials
Orthodontics
Patients
Plate material
polymers
Polymethyl methacrylate
Polymethyl Methacrylate - pharmacology
Polymethylmethacrylate
Printing industry
Reactors
Risk reduction
Silver
Silver - pharmacology
Streptococcus
Streptococcus infections
Streptococcus mutans
Streptococcus mutans - drug effects
Streptococcus mutans - ultrastructure
Surface Properties
Teeth
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Summary:Orthodontic retention has been proposed as a life‐long commitment for patients who desire to maintain straight teeth. However, the presence of foreign material increases risk of bacterial colonization and caries formation, of which Streptococcus mutans is a key contributor. Multiple studies have assessed the ability of silver to be added to base plate material and resist attachment of S. mutans. However, it does not appear that long‐term washout in connection with biofilm growth under physiologically relevant conditions has been taken into consideration. In this study, silver was added to base plate material and exposed to short‐ or long‐term washout periods. Materials were then assessed for their ability to resist biofilm formation of S. mutans using a drip flow reactor that modeled the human oral environment. Data indicated that silver was able to resist biofilm formation following short‐term washout, but long‐term washout periods resulted in a lack of ability to resist biofilm formation. These data will be important for future development of base plate materials to achieve long‐term antimicrobial efficacy to reduce risk of caries formation and benefit patients in the long term. © 2017 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 105A: 2632–2639, 2017.
ISSN:1549-3296
1552-4965
DOI:10.1002/jbm.a.36112