Significance of change in serum bilirubin in predicting left ventricular reverse remodeling and outcomes in heart failure patients with cardiac resynchronization therapy

• Published in: Journal of cardiology 2017-11, Vol.70 (5), p.416-419
• Main Authors: Hosoda, Junya, MD, Ishikawa, Toshiyuki, MD, FJCC, Matsumoto, Katsumi, MD, Iguchi, Kohei, MD, Matsushita, Hirooki, MD, Ogino, Yutaka, MD, Taguchi, Yuka, MD, Sugano, Teruyasu, MD, Ishigami, Tomoaki, MD, Kimura, Kazuo, MD, FJCC, Tamura, Kouichi, MD
• Format: Article
• Language: English
• Subjects: Aged; Bilirubin; Bilirubin - blood; Cardiac Resynchronization Therapy; Cardiovascular; Echocardiography; Female; Heart - diagnostic imaging; Heart - physiopathology; Heart Failure - blood; Heart Failure - diagnostic imaging; Heart Failure - physiopathology; Heart Failure - therapy; Hospitalization; Humans; Kaplan-Meier Estimate; Male; Middle Aged; Myocardium - pathology; Odds Ratio; Outcome; Treatment Outcome; Ventricular Function, Left; Ventricular Remodeling
• ISSN: 0914-5087; 1876-4738
• DOI: 10.1016/j.jjcc.2017.04.001

Abstract Background Research on the correlation of serum bilirubin level with cardiac function as well as outcomes in heart failure patients with cardiac resynchronization therapy (CRT) has not yet been reported. The aim of this study was to analyze the relationship between change in serum bilirubin level and left ventricular reverse remodeling, and also to clarify the impact of bilirubin change on clinical outcomes in CRT patients. Methods We evaluated 105 consecutive patients who underwent CRT. Patients who had no serum total-bilirubin data at both baseline and 3–9 months’ follow-up or had died less than 3 months after CRT implantation were excluded. Accordingly, a total of 69 patients were included in the present analysis. The patients were divided into two groups: decreased bilirubin group (serum total-bilirubin level at follow-up ≤ that at baseline; n = 48) and increased bilirubin group (serum total-bilirubin level at follow-up > that at baseline; n = 21). Results Mean follow-up period was 39.3 months. In the decreased bilirubin group, mean left ventricular end-systolic diameter decreased from 54.5 mm to 50.2 mm ( p = 0.001) and mean left ventricular ejection fraction increased significantly from 29.8% to 37.0% ( p = 0.001). In the increased bilirubin group, there was no significant change in echocardiographic parameters from baseline to follow-up. In Kaplan–Meyer analysis, cardiac mortality combined with heart failure hospitalization in the increased bilirubin group was significantly higher than that in the decreased bilirubin group (log-rank p = 0.018). Multivariate Cox regression analysis revealed that increased bilirubin was an independent predictor of cardiac mortality combined with heart failure hospitalization (OR = 2.66, p = 0.023). Conclusions The change in serum bilirubin is useful for assessment of left ventricular reverse remodeling and prediction of outcomes in heart failure patients with CRT.