SysFinder：A customized platform for search,comparison and assisted design of appropriate animal models based on systematic similarity

Animal models are increasingly gaining values by cross-comparisons of response or resistance to clinical agents used for patients.However,many disease mechanisms and drug effects generated from animal models are not transferable to human.To address these issues,we developed SysFinder（http：//lifecent...

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Bibliographic Details
Published in:Journal of genetics and genomics 2017-05, Vol.44 (5), p.251-258
Main Authors: Yang, Shuang, Zhang, Guoqing, Liu, Wan, Wang, Zhen, Zhang, Jifeng, Yang, Dongshan, Chen, Y. Eugene, Sun, Hong, Li, Yixue
Format: Article
Language:English
Subjects:
Animal models
Animals
ATP-Binding Cassette Transporters - genetics
ATP-Binding Cassette Transporters - metabolism
Computational Biology - methods
Data Mining
Dogs
Function similarity
Humans
Mice
Models, Animal
Neoplasms - genetics
Neoplasms - metabolism
Species Specificity
动物模型
定制
搜索
模型基
相似性
研究平台
系统
辅助设计
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Summary:Animal models are increasingly gaining values by cross-comparisons of response or resistance to clinical agents used for patients.However,many disease mechanisms and drug effects generated from animal models are not transferable to human.To address these issues,we developed SysFinder（http：//lifecenter.sgst.cn/SysFinder）,a platform for scientists to find appropriate animal models for translational research.SysFinder offers a ＂topic-centered＂ approach for systematic comparisons of human genes,whose functions are involved in a specific scientific topic,to the corresponding homologous genes of animal models.Scientific topic can be a certain disease,drug,gene function or biological pathway.SysFinder calculates multi-level similarity indexes to evaluate the similarities between human and animal models in specified scientific topics.Meanwhile,SysFinder offers species-specific information to investigate the differences in molecular mechanisms between humans and animal models.Furthermore,SysFinder provides a userfriendly platform for determination of short guide RNAs（sgRNAs） and homology arms to design a new animal model.Case studies illustrate the ability of SysFinder in helping experimental scientists.SysFinder is a useful platform for experimental scientists to carry out their research in the human molecular mechanisms.
ISSN:1673-8527
DOI:10.1016/j.jgg.2017.05.001