Association study of interleukin‐1 family, interleukin‐6, and its receptor gene polymorphisms in patients with recurrent aphthous stomatitis

Background Recurrent aphthous stomatitis (RAS) is one of the most common oral chronic ulcerative disease in which proinflammatory cytokines such as interleukin‐1 (IL‐1) and interleukin‐6 (IL‐6) are thought to play an important role. The aim of this study was to investigate the possible association b...

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Published in:Journal of oral pathology & medicine 2017-11, Vol.46 (10), p.1030-1035
Main Authors: Izakovicova Holla, Lydie, Valova, Simona, Borilova Linhartova, Petra, Bartova, Jirina, Petanova, Jitka, Kuklinek, Pavel, Fassmann, Antonin
Format: Article
Language:English
Subjects:
Adult
Aphthous stomatitis
case‐control study
Cytokines
Dentistry
Female
gene polymorphism
Genetic Association Studies
Haplotypes
Humans
Inflammation
Interleukin 1
Interleukin 1 receptors
Interleukin 6
Interleukin-1 - genetics
Interleukin-6 - genetics
Male
Middle Aged
Polymerase chain reaction
Polymorphism
Polymorphism, Single Nucleotide
Recurrence
Stomatitis
Stomatitis, Aphthous - genetics
Studies
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Summary:Background Recurrent aphthous stomatitis (RAS) is one of the most common oral chronic ulcerative disease in which proinflammatory cytokines such as interleukin‐1 (IL‐1) and interleukin‐6 (IL‐6) are thought to play an important role. The aim of this study was to investigate the possible association between polymorphisms in the IL‐1 cytokine family, IL‐6 or its receptor and RAS in the Czech population. Methods A total of 248 subjects, 184 healthy controls, and 64 patients with RAS were genotyped for IL‐1A‐889C>T, IL‐1B‐511C>T, IL‐1B+3953C>T, IL‐1RN86 bp variable number of tandem repeats (VNTRs) in intron 2, IL‐6‐597G>A, IL‐6‐572G>C, IL‐6‐174G>C, and IL‐6R+48992A>C by polymerase chain reaction (PCR) methods. Results No significant differences between investigated polymorphisms in healthy subjects and patients with RAS were detected (P>.05). In addition, complex analysis also revealed similar IL‐1 or IL‐6 haplotype frequencies between both groups (P>.05). Conclusions In conclusion, IL‐1 and IL‐6 or its receptor gene variants cannot be used as markers for identification of Czech patients with increased risk of recurrent aphthous stomatitis.
ISSN:0904-2512
1600-0714
DOI:10.1111/jop.12594