Direct Access to Isoindolin‐1‐one Scaffolds by Copper‐Catalyzed Divergent Cyclizations of 2‐Formylbenzonitrile and Diaryliodonium Salts

Copper‐catalyzed cascade transformations of 2‐formylbenzonitrile and diaryliodonium salts were carried out to efficiently afford isoindolin‐1‐one scaffolds. The process proceeds through a copper‐catalyzed tandem C–H/N–H arylation, producing two different isoindolin‐1‐one derivatives under different...

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Bibliographic Details
Published in:Advanced synthesis & catalysis 2017-04, Vol.359 (8), p.1283-1289
Main Authors: Liu, Li, Qiang, Jian, Bai, Shu‐Hua, Sung, Hui‐Ling, Miao, Chun‐Bao, Li, Jian
Format: Article
Language:English
Subjects:
2-formylbenzonitriles
Cascade chemical reactions
Cascades
Catalysis
Copper
copper-catalyzed reaction
Derivatives
diaryliodonium salts
isoindolin-1-ones
Scaffolds
Synthesis (chemistry)
tandem reactions
Transformations
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Summary:Copper‐catalyzed cascade transformations of 2‐formylbenzonitrile and diaryliodonium salts were carried out to efficiently afford isoindolin‐1‐one scaffolds. The process proceeds through a copper‐catalyzed tandem C–H/N–H arylation, producing two different isoindolin‐1‐one derivatives under different reaction conditions.
ISSN:1615-4150
1615-4169
DOI:10.1002/adsc.201601403