One-month spaceflight compromises the bone microstructure, tissue-level mechanical properties, osteocyte survival and lacunae volume in mature mice skeletons

The weightless environment during spaceflight induces site-specific bone loss. The 30-day Bion-M1 mission offered a unique opportunity to characterize the skeletal changes after spaceflight and an 8-day recovery period in mature male C57/BL6 mice. In the femur metaphysis, spaceflight decreased the t...

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Bibliographic Details
Published in:	Scientific reports 2017-06, Vol.7 (1), p.2659-12, Article 2659
Main Authors:	Gerbaix, Maude, Gnyubkin, Vasily, Farlay, Delphine, Olivier, Cécile, Ammann, Patrick, Courbon, Guillaume, Laroche, Norbert, Genthial, Rachel, Follet, Hélène, Peyrin, Françoise, Shenkman, Boris, Gauquelin-Koch, Guillemette, Vico, Laurence
Format:	Article
Language:	English
Subjects:	13/51 14 14/63 631/443/63 631/443/811 64/60 692/4023/1671/63 Adipose tissue Animal biology Animals Astronauts Biomechanical Phenomena Bone and Bones - pathology Bone and Bones - physiopathology Bone Density Bone loss Bone marrow Bone mass Bone resorption Bone Resorption - etiology Cancellous bone Cell death Collagen Diaphysis Femur Femur - pathology Femur - physiopathology Fourier transforms Habitats Housing conditions Human health and pathology Humanities and Social Sciences Landing behavior Life Sciences Male Mechanical properties Medical research Metaphysis Mice, Inbred C57BL Mineralization multidisciplinary Osteoclasts Osteocytes - pathology Osteocytes - physiology Radiation Science Science (multidisciplinary) Space Flight Spine Spine - pathology Spine - physiopathology Tissues and Organs Vertebrae Vertebrate Zoology Weightlessness - adverse effects
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