Early detection and integrated care for adolescents and young adults with psychotic disorders: the ACCESS III study

• Published in: Acta psychiatrica Scandinavica 2017-08, Vol.136 (2), p.188-200
• Main Authors: Lambert, M., Schöttle, D., Ruppelt, F., Rohenkohl, A., Sengutta, M., Luedecke, D., Nawara, L. A., Galling, B., Falk, A.‐L., Wittmann, L., Niehaus, V., Sarikaya, G., Rietschel, L., Gagern, C., Schulte‐Markwort, M., Unger, H.‐P., Ott, S., Romer, G., Daubmann, A., Wegscheider, K., Correll, C. U., Schimmelmann, B. G., Wiedemann, K., Bock, T., Gallinat, J., Karow, A.
• Format: Article
• Language: English
• Subjects: Adolescent; Adolescents; Adult; Age; bipolar disorder; Child & adolescent psychiatry; Children with disabilities; early detection; Early Diagnosis; Early Medical Intervention - statistics & numerical data; early psychosis; Female; Follow-Up Studies; Humans; integrated care; Linear Models; Patient Care - statistics & numerical data; Prospective Studies; Psychopathology; Psychosis; Psychotic Disorders - diet therapy; Psychotic Disorders - epidemiology; Quality of life; Remission; schizophrenia; Young Adult; Young adults
• ISSN: 0001-690X; 1600-0447
• DOI: 10.1111/acps.12762

Objective The objective of the study was to investigate whether a combined intervention composed of early detection plus integrated care (EDIC) enhances outcomes in patients with early psychosis compared to standard care (SC). Methods ACCESS III is a prospective non‐randomized historical control design 1‐year study examining the efficacy of EDIC (n = 120) vs. SC (n = 105) in patients aged 12–29 years. Primary outcome was the rate of ≥6 months combined symptomatic and functional remission. Additional outcomes comprised the reduction of DUP and course of psychopathology, functioning, quality of life, and satisfaction with care. Results In observed cases, 48.9% in the EDIC and 15.2% in the SC group reached the primary endpoint. Remission was predicted by EDIC (OR = 6.8, CI: 3.15–14.53, P