Structural and mechanistic basis of differentiated inhibitors of the acute pancreatitis target kynurenine-3-monooxygenase

Kynurenine-3-monooxygenase (KMO) is a key FAD-dependent enzyme of tryptophan metabolism. In animal models, KMO inhibition has shown benefit in neurodegenerative diseases such as Huntington’s and Alzheimer’s. Most recently it has been identified as a target for acute pancreatitis multiple organ dysfu...

Full description

Saved in:

Bibliographic Details
Published in:	Nature communications 2017-06, Vol.8 (1), p.15827-12, Article 15827
Main Authors:	Hutchinson, Jonathan P., Rowland, Paul, Taylor, Mark R. D., Christodoulou, Erica M., Haslam, Carl, Hobbs, Clare I., Holmes, Duncan S., Homes, Paul, Liddle, John, Mole, Damian J., Uings, Iain, Walker, Ann L., Webster, Scott P., Mowat, Christopher G., Chung, Chun-wa
Format:	Article
Language:	English
Subjects:	631/154 631/535/1266 639/638/45/535/1266 639/638/92 Animal models Animals Crystal structure Disease Enzyme Inhibitors - chemistry Enzyme Inhibitors - pharmacology Enzymes Escherichia coli - genetics Humanities and Social Sciences Humans Hydrogen Peroxide - metabolism Inhibitors Kynurenine 3-Monooxygenase - antagonists & inhibitors Kynurenine 3-Monooxygenase - chemistry Kynurenine 3-Monooxygenase - metabolism Models, Molecular Mortality multidisciplinary Multiple organ dysfunction syndrome Multiple Organ Failure - metabolism Neurodegeneration Pancreatitis Pancreatitis - metabolism Protein Domains Proteins Science Science (multidisciplinary) Sf9 Cells
Citations:	Items that this one cites Items that cite this one
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!