The influence of vitamin C on the interaction between acute mental stress and endothelial function

Purpose To determine whether orally administered vitamin C attenuates expected mental stress-induced reductions in brachial artery endothelial function as measured by flow-mediated dilation (FMD). Methods Fifteen men (21 ± 2 years) were given 1000 mg of vitamin C or placebo over two visits in a rand...

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Bibliographic Details
Published in:European journal of applied physiology 2017-08, Vol.117 (8), p.1657-1668
Main Authors: Plotnick, Meghan D., D’Urzo, Katrina A., Gurd, Brendon J., Pyke, Kyra E.
Format: Article
Language:English
Subjects:
Ascorbic acid
Ascorbic Acid - pharmacology
Biomedical and Life Sciences
Biomedicine
Blood Flow Velocity - drug effects
Blood pressure
Blood Pressure - drug effects
Blood Pressure - physiology
Brachial Artery - drug effects
Brachial Artery - physiopathology
Cortisol
Double-Blind Method
Endothelium, Vascular - drug effects
Endothelium, Vascular - physiopathology
Heart rate
Heart Rate - drug effects
Heart Rate - physiology
Hormones
Human Physiology
Humans
Hydrocortisone - analysis
Male
Occupational Medicine/Industrial Medicine
Oral administration
Original Article
Oxidative Stress - drug effects
Reactive oxygen species
Regional Blood Flow - drug effects
Saliva
Saliva - chemistry
Social interactions
Sports Medicine
Stress, Psychological - physiopathology
Vitamin C
Young Adult
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Summary:Purpose To determine whether orally administered vitamin C attenuates expected mental stress-induced reductions in brachial artery endothelial function as measured by flow-mediated dilation (FMD). Methods Fifteen men (21 ± 2 years) were given 1000 mg of vitamin C or placebo over two visits in a randomized, double-blinded, within-subject design. Acute mental stress was induced using the Trier Social Stress Test (TSST). Saliva samples for cortisol determination and FMD measures were obtained at baseline, pre-TSST, and 30 and 90-min post-TSST. An additional saliva sample was obtained immediately post-TSST. Cardiovascular stress reactivity was characterized by changes in heart rate (HR) and mean arterial pressure (MAP). Results A significant stress response was elicited by the TSST in both conditions [MAP, HR, and salivary cortisol increased ( p  
ISSN:1439-6319
1439-6327
DOI:10.1007/s00421-017-3655-4