A dose–response relation exists between different classes of pre-gravid obesity and selected perinatal outcomes

Objective To examine if a “dose–response” relation exists between different classes of pre-gravid obesity and selected perinatal outcomes. Methods We evaluated 16,566 obese mothers, including 12,064 (72.8%), 3410 (20.6%), and 1092 (6.6%) with obesity class I, II, and III, respectively. We compared m...

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Bibliographic Details
Published in:Archives of gynecology and obstetrics 2017-09, Vol.296 (3), p.465-468
Main Authors: Trojner Bregar, Andreja, Tul, Nataša, Fabjan Vodušek, Vesna, Verdenik, Ivan, Lucovnik, Miha, Janša, Vid, Blickstein, Isaac
Format: Article
Language:English
Subjects:
Adult
Birth Weight
Body Mass Index
Cesarean Section - adverse effects
Diabetes, Gestational - epidemiology
Endocrinology
Female
Gestational Age
Gynecology
Health risk assessment
Human Genetics
Humans
Hypertension
Hypertension, Pregnancy-Induced - epidemiology
Infant, Newborn
Maternal Age
Maternal-Fetal Medicine
Medicine
Medicine & Public Health
Obesity
Obesity - complications
Obstetrics/Perinatology/Midwifery
Parity
Pre-Eclampsia - epidemiology
Pregnancy
Pregnancy Outcome
Risk Factors
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Summary:Objective To examine if a “dose–response” relation exists between different classes of pre-gravid obesity and selected perinatal outcomes. Methods We evaluated 16,566 obese mothers, including 12,064 (72.8%), 3410 (20.6%), and 1092 (6.6%) with obesity class I, II, and III, respectively. We compared maternal age, primiparity, gestational age at birth, birth weight, GDM, hypertensive disorders, and the incidence of cesarean sections. Results There was a significantly increased incidence (from class I to class III) for GDM (8.5–14.4%), chronic hypertension (2.8–9.0%), gestational hypertension (6.7–14.2%), and for preeclampsia (5.3–9.3%). No such relationship existed for birth weight and gestational duration. Conclusion Classes of obesity during pregnancy exhibit a “dose–response” relationship with maternal morbidity, but no such relationship was found with pregnancy duration and birth weight.
ISSN:0932-0067
1432-0711
DOI:10.1007/s00404-017-4441-6