Combined effects of physical inactivity and acute hyperglycemia on arterial distensibility

Arterial distensibility, an independent predictor of cardiovascular events, is transiently increased with acute hyperglycemia (AHG) in healthy individuals. Whether this response interacts with physical inactivity remains unknown. We examined the effects of short-term bed rest (BR) on the response of...

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Bibliographic Details
Published in:Vascular medicine (London, England) England), 2017-08, Vol.22 (4), p.285-291
Main Authors: Montero, David, Dandanell, Sune, Oberholzer, Laura, Keiser, Stefanie, Breenfeldt-Andersen, Andreas, Haider, Thomas, Merlini, Mario, Meinild-Lundby, Anne-Kristine, Lundby, Carsten
Format: Article
Language:English
Subjects:
Acute Disease
Adult
Albumin
Bed rest
Bed Rest - adverse effects
Biomarkers - blood
Blood
Blood Glucose - metabolism
Blood Volume
Cardiovascular Diseases - etiology
Cardiovascular Diseases - physiopathology
Carotid Arteries - diagnostic imaging
Carotid Arteries - physiopathology
Carotid artery
Exercise
Glucose
Glucose Tolerance Test
Health risk assessment
Healthy Volunteers
Hemodynamics
Humans
Hyperglycemia
Hyperglycemia - blood
Hyperglycemia - complications
Hyperglycemia - diagnosis
Immobilization
Ingestion
Insulin
Insulin - blood
Insulin Resistance
Male
Physical activity
Plasmas (physics)
Regression analysis
Restoration
Risk Factors
Time Factors
Ultrasonography
Ultrasound
Vascular Stiffness
Young Adult
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Summary:Arterial distensibility, an independent predictor of cardiovascular events, is transiently increased with acute hyperglycemia (AHG) in healthy individuals. Whether this response interacts with physical inactivity remains unknown. We examined the effects of short-term bed rest (BR) on the response of carotid artery distensibility (CD) to AHG, and the influence of underlying changes in insulin resistance and blood volume. CD was assessed with ultrasonography before as well as 30 and 120 minutes following ingestion of 75 g of glucose prior to and after 3 days of BR in 15 healthy male volunteers. Plasma insulin/glucose concentrations and blood volumes were concomitantly determined. On day 4 of BR, blood volume was re-established to pre-BR levels by albumin infusion and CD and insulin/glucose concentrations were determined as in the previous experimental days. Basal CD was not affected by BR. AHG increased CD before and after BR but reached a higher peak increment after BR (12% vs 60% at 30 min OGTT, p=0.028). BR also increased the plasma insulin concentration during AHG (p=0.007). In regression analyses, plasma insulin and glucose concentrations were positively correlated to CD, particularly after BR (r=0.31, p
ISSN:1358-863X
1477-0377
DOI:10.1177/1358863X17712103