Passive smoking and mortality from aortic dissection and aneurysm

• Published in: Atherosclerosis 2017-08, Vol.263, p.145-150
• Main Authors: Kihara, Tomomi, Yamagishi, Kazumasa, Iso, Hiroyasu, Tamakoshi, Akiko
• Format: Article
• Language: English
• Subjects: Adult; Aged; Aneurysm - etiology; Aneurysm - mortality; Aneurysm, Dissecting - etiology; Aneurysm, Dissecting - mortality; Aorta; Cardiovascular; Cardiovascular disease; Cohort Studies; Environmental tobacco smoke; Epidemiology; Female; Follow-Up Studies; Humans; Japan; Male; Middle Aged; Multivariate Analysis; Proportional Hazards Models; Secondhand smoke; Smoking - adverse effects; Tobacco Smoke Pollution - adverse effects
• ISSN: 0021-9150; 1879-1484
• DOI: 10.1016/j.atherosclerosis.2017.06.022

Abstract Background and aims Evidence on the association between passive smoking and risk of aortic dissection or aneurysm is limited. This study aimed to investigate whether passive smoking increases risk of mortality from aortic dissection or aneurysm. Methods The Japan Collaborative Cohort (JACC) Study is a prospective community-based cohort study begun in 1988–90 and followed up to the end of 2009. We examined 48,677 individuals (mean age, 56 years; women, 46%) without history of stroke, coronary heart disease, or cancer, who provided valid responses to a lifestyle questionnaire including questions on active and passive smoking. We used 3 categories (passive smoking out of home, passive smoking at home, and passive smoking out of or at home combined) to divide never-smokers into 3 exposure groups: low, intermediate, and high exposures, respectively. The endpoint was underlying cause of death from aortic dissection or aneurysm. Results During the median 19-year follow-up of 48,677 study participants, 66 died of aortic dissection, and 75 of aortic aneurysm. Multivariable hazard ratios (95% confidence intervals) for the high passive-smoking group as compared with the low passive-smoking group were 2.45 (1.02–5.88) out of home, 1.82 (0.84–3.96) at home, and 2.35 (1.09–5.09) out of or at home combined. The corresponding hazard ratios for current smokers as compared with the low passive-smoking group were 3.97 (2.14–7.39), 3.41 (1.84–6.32) and 4.09 (1.99–8.39), respectively. Conclusions Out-of-home passive smoking and out-of- or at-home combined passive smoking were associated with increased mortality from aortic dissection or aneurysm.