Xyloglucan: A functional biomacromolecule for drug delivery applications

• Published in: International journal of biological macromolecules 2017-11, Vol.104 (Pt A), p.799-812
• Main Authors: Kulkarni, Abhijeet D., Joshi, Aditya A., Patil, Chirag L., Amale, Prasad D., Patel, Harun M., Surana, Sanjay J., Belgamwar, Veena S., Chaudhari, Kapil S., Pardeshi, Chandrakantsing V.
• Format: Article
• Language: English
• Subjects: Chemical Phenomena; Drug Carriers - chemical synthesis; Drug Carriers - chemistry; Drug Carriers - isolation & purification; Drug delivery; Glucans - chemical synthesis; Glucans - chemistry; Glucans - isolation & purification; Humans; In situ gel; Mucoadhesion; Surface-modification; Thiolated xyloglucan; Xylans - chemical synthesis; Xylans - chemistry; Xylans - isolation & purification; Xyloglucan
• ISSN: 0141-8130; 1879-0003
• DOI: 10.1016/j.ijbiomac.2017.06.088

•Xyloglucan is a polysaccharide obtained from Tamarind seeds or kernel.•The important properties of xyloglucan include in situ gelation and mucoadhesion.•Xyloglucan can be modified to its thiolated or carboxymethylated derivative.•Xyloglucan has a wide range of applications in pharmaceutical and biomedical fields.•Present review is the state of the art collection on various aspects of xyloglucan. The near future of drug delivery system would lie in the search of a versatile and innocuous material, based mostly on the natural resources. The tamarind seed xyloglucan (XG) is a natural neutral hemicellulose and a hydrophilic polysaccharide consisting of a main chain of glucan backbone with xylose and galactose side chains. XG is endowed with idiosyncratic mucoadhesive and in situ gelling properties which rated XG as an attractive, functional polymer for numerous drug delivery applications. In milieu of this, the present review is designed to underline the plausible potential of XG or XG-based systems in drug delivery. The feasibility of surface-tailoring, the flexibility of chemical-modification, and the possibility as ligand-conjugations grant XG an extraordinary consideration in the scientific territory. The authors are hopeful that the versatility of XG would meet the expectations of regulatory authorities and the XG-based products will serve the therapeutic needs of the community in the future, if sufficiently investigated and promising outcomes are obtained in human subjects.