A General Strategy for the Construction of Functionalized Azaindolines via Domino Palladium-Catalyzed Heck Cyclization/Suzuki Coupling

The preparation of substituted azaindolines utilizing a domino palladium-catalyzed Heck cyclization/Suzuki coupling is described. The approach is amenable for the construction of all four azaindoline isomers. A range of functional groups such as esters, amides, ketones, sulfones, amines, and nitrile...

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Bibliographic Details
Published in:Organic letters 2017-07, Vol.19 (13), p.3616-3619
Main Authors: Schempp, Tabitha T, Daniels, Blake E, Staben, Steven T, Stivala, Craig E
Format: Article
Language:English
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Summary:The preparation of substituted azaindolines utilizing a domino palladium-catalyzed Heck cyclization/Suzuki coupling is described. The approach is amenable for the construction of all four azaindoline isomers. A range of functional groups such as esters, amides, ketones, sulfones, amines, and nitriles are all tolerated under the reaction conditions.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.7b01606