Autoantibodies against four kinds of neurotransmitter receptors in psychiatric disorders

There is a hypothesis that autoimmune abnormalities in neurotransmitter receptors might cause some psychiatric disorders. Using a sensitive radioligand assay, we detected serum autoantibodies to recombinant human muscarinic cholinergic receptor 1 (CHRM1, 34.4%), mu-opioid receptor (OPRM1, 13.1%), 5-...

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Bibliographic Details
Published in:Journal of neuroimmunology 2003-08, Vol.141 (1), p.155-164
Main Authors: Tanaka, Susumu, Matsunaga, Hidenori, Kimura, Masahiro, Tatsumi, Ke-ita, Hidaka, Yoh, Takano, Toru, Uema, Takeshi, Takeda, Masatoshi, Amino, Nobuyuki
Format: Article
Language:English
Subjects:
Adult
Autoantibodies - biosynthesis
Autoantibodies - blood
Autoantibody
Autoimmune Diseases - immunology
Depressive Disorder - immunology
Female
Humans
Male
Mental Disorders - immunology
Middle Aged
Mood disorder
Mood Disorders - immunology
Neuroleptic malignant syndrome
Neuroleptic Malignant Syndrome - immunology
Neurotransmitter receptor
Radioligand Assay
Receptor, Muscarinic M1
Receptor, Serotonin, 5-HT1A - immunology
Receptors, Dopamine D2 - immunology
Receptors, Muscarinic - immunology
Receptors, Opioid - immunology
Schizophrenia - classification
Schizophrenia - immunology
Schizophrenic disorder
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Summary:There is a hypothesis that autoimmune abnormalities in neurotransmitter receptors might cause some psychiatric disorders. Using a sensitive radioligand assay, we detected serum autoantibodies to recombinant human muscarinic cholinergic receptor 1 (CHRM1, 34.4%), mu-opioid receptor (OPRM1, 13.1%), 5-hydroxytryptamine receptor 1A (HTR1A, 7.4%), and dopamine receptor D2 (DRD2, 4.9%) in 122 psychiatric patients. Positive antibodies to CHRM1 were found in 34.1%, 34.9%, 33.3%, and 9.1% of patients with schizophrenic disorders ( n=44), mood disorders ( n=63), other psychiatric disorders ( n=15) and autoimmune diseases ( n=33), respectively. All three patients with neuroleptic maliganant syndrome had high activities of autoantibodies to CHRM1, OPRM1, and/or HTR1A. Our data suggest that autoimmunity to neurotransmitter receptors might be associated with the induction of psychiatric symptoms and have some relation to neuroleptic malignant syndrome.
ISSN:0165-5728
1872-8421
DOI:10.1016/S0165-5728(03)00252-2