Effectiveness of local therapy for stage I non–small-cell lung cancer in nonagenarians

Stage I non–small-cell lung cancer is potentially curable, yet older patients undergo treatment at lower rates than younger patients. This analysis sought to describe the treatment outcomes of nonagenarians with stage I non–small-cell lung cancer to better guide treatment decisions in this populatio...

Full description

Saved in:
Bibliographic Details
Published in:Surgery 2017-09, Vol.162 (3), p.640-651
Main Authors: Arnold, Brian N., Thomas, Daniel C., Rosen, Joshua E., Salazar, Michelle C., Detterbeck, Frank C., Blasberg, Justin D., Boffa, Daniel J., Kim, Anthony W.
Format: Article
Language:English
Subjects:
Aged, 80 and over
Carcinoma, Non-Small-Cell Lung - mortality
Carcinoma, Non-Small-Cell Lung - pathology
Carcinoma, Non-Small-Cell Lung - therapy
Confidence Intervals
Databases, Factual
Disease-Free Survival
Female
Geriatric Assessment
Humans
Kaplan-Meier Estimate
Logistic Models
Lung Neoplasms - mortality
Lung Neoplasms - pathology
Lung Neoplasms - therapy
Male
Multivariate Analysis
Neoplasm Invasiveness - pathology
Neoplasm Staging
Odds Ratio
Pneumonectomy - methods
Pneumonectomy - mortality
Proportional Hazards Models
Radiotherapy - methods
Registries
Risk Assessment
Secondary Prevention
Survival Analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Stage I non–small-cell lung cancer is potentially curable, yet older patients undergo treatment at lower rates than younger patients. This analysis sought to describe the treatment outcomes of nonagenarians with stage I non–small-cell lung cancer to better guide treatment decisions in this population. The National Cancer DataBase was queried for patients age ≥90 years old with stage I non–small-cell lung cancer (tumors ≤4 cm). Patients were divided into 3 groups: local therapy, other therapy, or no treatment. The primary outcomes were 5-year overall and relative survival. Of the 616 patients identified, 33% (202) were treated with local therapy, 34% (207) were treated with other therapy, and 34% (207) underwent no treatment. Compared with local therapy, overall mortality was significantly higher with no treatment (hazard ratio 2.50, 95% confidence interval, 1.95–3.21) and other therapy (hazard ratio 1.43, 95% confidence interval, 1.11–1.83). The 5-year relative survival was 81% for local therapy, 49% for other therapy, and 32% for no treatment (P 
ISSN:0039-6060
1532-7361
DOI:10.1016/j.surg.2017.04.025