Longitudinal assessment of bone loss using quantitative ultrasound in a blood-induced arthritis rabbit model

Introduction Osteoporosis is common in haemophilic arthropathy. Quantitative ultrasound (QUS) can be a suitable alternative for dual‐energy x‐ray absorptiometry for diagnosing osteoporosis in haemophiliacs due to its lack of ionizing radiation, and ease to use. Aim We investigated the intra‐ and int...

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Bibliographic Details
Published in:Haemophilia : the official journal of the World Federation of Hemophilia 2015-09, Vol.21 (5), p.e402-e410
Main Authors: Wang, K. C., Amirabadi, A., Moineddin, R., Jong, R., Tomlinson, C., Doria, A. S.
Format: Article
Language:English
Subjects:
Animals
Arthritis - blood
Arthritis - complications
Autopsy
blood-induced arthritis model
Bone Resorption - complications
Bone Resorption - diagnostic imaging
Disease Models, Animal
haemophilia
Injections, Intra-Articular
knees
Longitudinal Studies
osteoporosis
quantitative ultrasound
rabbit
Rabbits
Reproducibility of Results
Ultrasonography
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Summary:Introduction Osteoporosis is common in haemophilic arthropathy. Quantitative ultrasound (QUS) can be a suitable alternative for dual‐energy x‐ray absorptiometry for diagnosing osteoporosis in haemophiliacs due to its lack of ionizing radiation, and ease to use. Aim We investigated the intra‐ and inter‐operator reliability of QUS, its responsiveness to bone growth, its ability to differentiate bone adjacent to blood‐injected vs. control joints, and the effect of soft tissues on the speed of sound (SOS) QUS values in a juvenile white New Zealand rabbit model of blood‐induced arthritis. Methods Eight of 16 rabbits were injected with autologous blood (0.1 mL kg−1) 8 times over a 17‐week period, the remaining eight rabbits served as controls. SOS was measured at baseline, weeks 8 and 17 in vivo and after the bones were excised on week 17. Results Intra‐ and inter‐operator coefficients of variation for QUS data were 60% for 22/27 (81.5%) of bones assessed. The level of interval increase in SOS values from baseline to week 17 was significantly different in tibiae of injected, contralateral to injected and non‐injected knee groups by anova (P = 0.01). In vivo (mean ± SD, 4147.17 ± 96.27 m s−1) and postmortem (4457.85 ± 104.00 m s−1) measurements on week 17 differed (P 
ISSN:1351-8216
1365-2516
DOI:10.1111/hae.12743