History of winning remodels thalamo-PFC circuit to reinforce social dominance

• Published in: Science (American Association for the Advancement of Science) 2017-07, Vol.357 (6347), p.162-168
• Main Authors: Zhou, Tingting, Zhu, Hong, Fan, Zhengxiao, Wang, Fei, Chen, Yang, Liang, Hexing, Yang, Zhongfei, Zhang, Lu, Lin, Longnian, Zhan, Yang, Wang, Zheng, Hu, Hailan
• Format: Article
• Language: English
• Subjects: Adaptation, Psychological - physiology; Animals; Brain; Circuits; Dominance; In vivo methods and tests; Long-term depression; Long-term potentiation; Long-Term Potentiation - physiology; Long-Term Synaptic Depression - physiology; Mice; Mice, Inbred C57BL; Nerve Net - physiology; Neural networks; Optogenetics; Prefrontal cortex; Prefrontal Cortex - physiology; Reinforcement (Psychology); Social Dominance; Synapses; Thalamus; Thalamus - physiology
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.aak9726

Mental strength and history of winning play an important role in the determination of social dominance. However, the neural circuits mediating these intrinsic and extrinsic factors have remained unclear. Working in mice, we identified a dorsomedial prefrontal cortex (dmPFC) neural population showing “effort”-related firing during moment-to-moment competition in the dominance tube test. Activation or inhibition of the dmPFC induces instant winning or losing, respectively. In vivo optogenetic-based long-term potentiation and depression experiments establish that the mediodorsal thalamic input to the dmPFC mediates long-lasting changes in the social dominance status that are affected by history of winning. The same neural circuit also underlies transfer of dominance between different social contests. These results provide a framework for understanding the circuit basis of adaptive and pathological social behaviors.