The functional relevance of diffusion tensor imaging in comparison to conventional MRI in patients with cervical compressive myelopathy

Objective To determine the functional relevance of diffusion tensor imaging (DTI) metrics and conventional MRI (signal intensity change in T2, compression ratio) by measuring the correlation of these parameters with clinical outcome measured by the modified Japanese Orthopedic Association (mJOA) sco...

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Bibliographic Details
Published in:Skeletal radiology 2017-11, Vol.46 (11), p.1477-1486
Main Authors: Yang, Young-Mi, Yoo, Woo-Kyoung, Yoo, Je Hyun, Kwak, Yoon Hae, Oh, Jae-Keun, Song, Ji-Sun, Kim, Seok Woo
Format: Article
Language:English
Subjects:
Anisotropy
Central nervous system diseases
Cervical Vertebrae - diagnostic imaging
Cervical Vertebrae - pathology
Compression
Compression ratio
Compression tests
Correlation analysis
Diffusion coefficient
Diffusion Tensor Imaging - methods
Female
Functional magnetic resonance imaging
Humans
Imaging
Magnetic resonance imaging
Magnetic Resonance Imaging - methods
Male
Medical colleges
Medical diagnosis
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Middle Aged
Nuclear Medicine
Orthopedics
Parameter modification
Pathology
Patients
Prospective Studies
Radiology
Scientific Article
Sensitivity and Specificity
Spinal cord
Spinal Cord Compression - diagnostic imaging
Spinal Cord Compression - pathology
Spinal Stenosis - diagnostic imaging
Spinal Stenosis - pathology
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Summary:Objective To determine the functional relevance of diffusion tensor imaging (DTI) metrics and conventional MRI (signal intensity change in T2, compression ratio) by measuring the correlation of these parameters with clinical outcome measured by the modified Japanese Orthopedic Association (mJOA) score. Materials and methods A total of 20 cervical myelopathy (CM) patients participated in this prospective cohort study. The severities of CM were assessed using the mJOA score. Conventional MRIs (T2-weighted images) measuring the signal changes of spinal cords and the degree of compression at the lesion level and DTI metrics [fractional anisotropy (FA), apparent diffusion coefficient (ADC)] at each lesion and below each lesion (C7/T1) level were acquired using a 3-T Achieva MRI. These parameters were correlated with the mJOA scores to determine the functional relevance. Results Ninety percent of CM patients showed signal changes and 30 % of patients noted a more than 40% canal compression ratio in conventional MRIs at the lesion level; however, these findings were not correlated with the mJOA score ( p  
ISSN:0364-2348
1432-2161
DOI:10.1007/s00256-017-2713-7