Vitamin D levels in childhood and adolescence and cardiovascular risk factors in a cohort of healthy Australian children

•A cohort of children was measured into adolescence for 25OHD and CVD risk factors.•From age 8–15 mean serum 25OHD levels decreased significantly from 94 to 63 nmol/L.•25OHD @ 8yrs in boys was associated with cholesterol and triglyceride levels @ 15yrs.•At 15yrs lower 25OHD was associated with highe...

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Bibliographic Details
Published in:The Journal of steroid biochemistry and molecular biology 2018-03, Vol.177, p.270-277
Main Authors: Ke, Larry, Mason, Rebecca S., Baur, Louise A., Cowell, Chris T., Liu, Xiaoying, Garnett, Sarah P., Brock, Kaye E.
Format: Article
Language:English
Subjects:
25OHD
Adolescent
Adolescents
Anthropometry
Australia - epidemiology
Boys
Cardiovascular Diseases - epidemiology
Child
Children
Cohort Studies
CVD risk factors
Diastolic blood pressure
Female
Humans
Male
Risk Factors
Sum of skinfolds
Total body fat
Total cholesterol
Triglycerides
Vitamin D - analogs & derivatives
Vitamin D - blood
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Summary:•A cohort of children was measured into adolescence for 25OHD and CVD risk factors.•From age 8–15 mean serum 25OHD levels decreased significantly from 94 to 63 nmol/L.•25OHD @ 8yrs in boys was associated with cholesterol and triglyceride levels @ 15yrs.•At 15yrs lower 25OHD was associated with higher body fat.•If confirmed in larger studies these findings may have public health consequences. As the prevalence of obesity appears to be increasing in Australia’s youth the overall objective of this study was to examine serum 25-hydroxyvitamin D (25OHD) concentrations in a cohort of 8-year-olds (n=249) followed up at age 15 (n=162) and explore associations between 25OHD with cardiovascular disease (CVD) risk factors in these populations. This was done in two stages: the first, two cross-sectional analyses (at ages 8 and 15); and the second, a prospective analysis from age 8 to 15. At both ages data on 25OHD, blood lipids, and anthropometry were measured. Date of blood draw was used as a surrogate of sunlight exposure. Results were then analysed by multivariate linear analyses taking into account interaction and confounding. Mean 25OHD concentrations decreased from 94±25nmol/L to 63±16nmol/L between age 8 and 15 years (p
ISSN:0960-0760
1879-1220
DOI:10.1016/j.jsbmb.2017.07.010