Can pharmacological manipulation of LTP favor the effects of motor rehabilitation in multiple sclerosis?

Background: Synaptic plasticity, the basic mechanism of clinical recovery after brain lesion, can also remarkably influence the clinical course of multiple sclerosis (MS). Physical rehabilitation represents the main treatment option to promote synaptic long-term potentiation (LTP) and to enhance spo...

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Bibliographic Details
Published in:Multiple sclerosis 2018-06, Vol.24 (7), p.902-907
Main Authors: Stampanoni Bassi, Mario, Leocani, Letizia, Comi, Giancarlo, Iezzi, Ennio, Centonze, Diego
Format: Article
Language:English
Subjects:
Animals
Cytokines
Drug therapy
Exercise Therapy - methods
Humans
Inflammation
Long-term potentiation
Long-Term Potentiation - drug effects
Long-Term Potentiation - physiology
Multiple sclerosis
Multiple Sclerosis - drug therapy
Multiple Sclerosis - rehabilitation
Neurological diseases
Recovery of function
Recovery of Function - drug effects
Recovery of Function - physiology
Rehabilitation
Spontaneous recovery
Synaptic plasticity
Synaptic transmission
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Summary:Background: Synaptic plasticity, the basic mechanism of clinical recovery after brain lesion, can also remarkably influence the clinical course of multiple sclerosis (MS). Physical rehabilitation represents the main treatment option to promote synaptic long-term potentiation (LTP) and to enhance spontaneous recovery of neurological deficits. Objectives: To overview the role of pharmacological treatment and physical rehabilitation in modulating LTP and enhancing clinical recovery in MS. Results: Drug-induced LTP enhancement can be effectively used to promote functional recovery, alone or combined with rehabilitation. Also, as inflammatory cytokines alter synaptic transmission and plasticity in MS, pharmacological resolution of inflammation can positively influence clinical recovery. Finally, physical exercise could be an independent factor able to preserve or enhance LTP reserve both influencing signaling pathways involved in plasticity induction and maintenance, and decreasing inflammation. Future directions: Better knowledge of LTP determinants may be useful to design specific strategies to promote recovery after a relapse and to reduce the progressive neurological deterioration in MS patients.
ISSN:1352-4585
1477-0970
DOI:10.1177/1352458517721358