Loading…

Comorbid autoimmune diseases in patients with pemphigus: a nationwide case-control study in Taiwan

Background Previous studies have proposed the association between pemphigus and several autoimmune diseases, but no large-scale study has been reported. Objectives To delineate the association between pemphigus and autoimmune diseases including psoriasis. Materials & Methods A total of 1,998 pat...

Full description

Saved in:
Bibliographic Details
Published in:EJD. European journal of dermatology 2017-08, Vol.27 (4), p.375-381
Main Authors: Chiu, Yun-Wen, Chen, Yen-Da, Hua, Tuan-Chun, Wu, Chi-Hung, Liu, Han-Nan, Chang, Yun-Ting
Format: Article
Language:English
Subjects:
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Background Previous studies have proposed the association between pemphigus and several autoimmune diseases, but no large-scale study has been reported. Objectives To delineate the association between pemphigus and autoimmune diseases including psoriasis. Materials & Methods A total of 1,998 patients with pemphigus and 7,992 control subjects were enrolled from the National Health Insurance Research Database in Taiwan from 1997 to 2010. The odds of comorbidities between these two groups were analysed by multivariate logistic regression. Results Compared with control subjects, patients with pemphigus were much more likely to have Sjögren’s syndrome (odds ratio [OR]: 15.0; 95% confidence interval [CI]: 3.16-71.5), psoriasis (OR: 7.18; 95% CI: 5.55-9.29), systemic lupus erythematosus (OR: 4.46; 95% CI: 1.88-10.6), and alopecia areata (OR: 2.68; 95% CI: 1.26-5.67). According to gender-stratified analyses, however, the association between pemphigus and Sjögren’s syndrome or alopecia areata was found to be significant only in the female patients. Conclusion We confirm the association between pemphigus and some autoimmune diseases, including Sjögren’s syndrome, systemic lupus erythematosus, and alopecia areata. In addition, we present the novel finding that patients with pemphigus have an increased risk of psoriasis.
ISSN:1167-1122
1952-4013
DOI:10.1684/ejd.2017.3060