Measurement Challenges at Low Blood Lead Levels

In 2012, the Centers for Disease Control and Prevention (CDC) adopted its Advisory Committee on Childhood Lead Poisoning Prevention recommendation to use a population-based reference value to identify children and environments associated with lead hazards. The current reference value of 5 μg/dL is c...

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Published in:Pediatrics (Evanston) 2017-08, Vol.140 (2)
Main Authors: Caldwell, Kathleen L, Cheng, Po-Yung, Jarrett, Jeffery M, Makhmudov, Amir, Vance, Kathryn, Ward, Cynthia D, Jones, Robert L, Mortensen, Mary E
Format: Article
Language:English
Subjects:
Blood
Blood levels
Blood tests
Child, Preschool
Children
Children & youth
Contamination
Demographics
Diagnosis
Disease control
Environmental health
Female
Hazard identification
Humans
Infant
Laboratory Proficiency Testing
Lead
Lead - blood
Lead in the body
Lead poisoning
Lead Poisoning - blood
Lead Poisoning - prevention & control
Male
Mass Screening
Measurement
Medical examination
Nutrition Surveys
Pediatrics
Prevention
Quality assurance
Quality Assurance, Health Care
Reference Values
United States
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container_title Pediatrics (Evanston)
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creator Caldwell, Kathleen L
Cheng, Po-Yung
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Makhmudov, Amir
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Ward, Cynthia D
Jones, Robert L
Mortensen, Mary E
description In 2012, the Centers for Disease Control and Prevention (CDC) adopted its Advisory Committee on Childhood Lead Poisoning Prevention recommendation to use a population-based reference value to identify children and environments associated with lead hazards. The current reference value of 5 μg/dL is calculated as the 97.5th percentile of the distribution of blood lead levels (BLLs) in children 1 to 5 years old from 2007 to 2010 NHANES data. We calculated and updated selected percentiles, including the 97.5th percentile, by using NHANES 2011 to 2014 blood lead data and examined demographic characteristics of children whose blood lead was ≥90th percentile value. The 97.5th percentile BLL of 3.48 µg/dL highlighted analytical laboratory and clinical interpretation challenges of blood lead measurements ≤5 μg/dL. Review of 5 years of results for target blood lead values
doi_str_mv 10.1542/peds.2017-0272
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source EZB Electronic Journals Library
subjects Blood
Blood levels
Blood tests
Child, Preschool
Children
Children & youth
Contamination
Demographics
Diagnosis
Disease control
Environmental health
Female
Hazard identification
Humans
Infant
Laboratory Proficiency Testing
Lead
Lead - blood
Lead in the body
Lead poisoning
Lead Poisoning - blood
Lead Poisoning - prevention & control
Male
Mass Screening
Measurement
Medical examination
Nutrition Surveys
Pediatrics
Prevention
Quality assurance
Quality Assurance, Health Care
Reference Values
United States
title Measurement Challenges at Low Blood Lead Levels
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