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Measurement Challenges at Low Blood Lead Levels

In 2012, the Centers for Disease Control and Prevention (CDC) adopted its Advisory Committee on Childhood Lead Poisoning Prevention recommendation to use a population-based reference value to identify children and environments associated with lead hazards. The current reference value of 5 μg/dL is c...

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Bibliographic Details
Published in:Pediatrics (Evanston) 2017-08, Vol.140 (2)
Main Authors: Caldwell, Kathleen L, Cheng, Po-Yung, Jarrett, Jeffery M, Makhmudov, Amir, Vance, Kathryn, Ward, Cynthia D, Jones, Robert L, Mortensen, Mary E
Format: Article
Language:English
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Summary:In 2012, the Centers for Disease Control and Prevention (CDC) adopted its Advisory Committee on Childhood Lead Poisoning Prevention recommendation to use a population-based reference value to identify children and environments associated with lead hazards. The current reference value of 5 μg/dL is calculated as the 97.5th percentile of the distribution of blood lead levels (BLLs) in children 1 to 5 years old from 2007 to 2010 NHANES data. We calculated and updated selected percentiles, including the 97.5th percentile, by using NHANES 2011 to 2014 blood lead data and examined demographic characteristics of children whose blood lead was ≥90th percentile value. The 97.5th percentile BLL of 3.48 µg/dL highlighted analytical laboratory and clinical interpretation challenges of blood lead measurements ≤5 μg/dL. Review of 5 years of results for target blood lead values
ISSN:0031-4005
1098-4275
DOI:10.1542/peds.2017-0272