High prevalence of gallstone disease in rheumatoid arthritis: A new comorbidity related to dyslipidemia?

Abstract Objective To assess the prevalence of gallstone disease and identify associated risk factors in rheumatoid arthritis (RA) patients compared to the general population. Methods Eighty-four women with rheumatoid arthritis were included in the study. Each patient was assessed via a structured i...

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Published in:Reumatología clinica 2019-03, Vol.15 (2), p.84-89
Main Authors: García-Gómez, María Carmen, de Lama, Eugenia, Ordoñez-Palau, Sergi, Nolla, Joan Miquel, Corbella, Emili, Pintó, Xavier
Format: Article
Language:English
Subjects:
Artritis reumatoide
Cholecystectomy
Colecistectomía
Comorbidity
Comorbilidad
Gallstones
Lipids
Lipoproteins
Lipoproteínas
Litiasis biliar
Lípidos
Rheumatoid arthritis
Rheumatology
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Summary:Abstract Objective To assess the prevalence of gallstone disease and identify associated risk factors in rheumatoid arthritis (RA) patients compared to the general population. Methods Eighty-four women with rheumatoid arthritis were included in the study. Each patient was assessed via a structured interview, physical examination, abdominal ultrasound and blood test including lipid profile. The prevalence of gallstone disease in rheumatoid arthritis was compared with data from a study of the Spanish population matched by age groups. Results Twenty-eight of the 84 women had gallstone disease (33.3%). RA women with and without gallstone disease were similar in most of the variables assessed, except for older age and menopausal status in the former. A greater prevalence of gallstone disease was seen in rheumatoid arthritis patients compared to the general population of the same age; however, the differences were significant only in women aged 60 or older (45.5% versus 23.1% respectively, P -value .008). The age-adjusted OR of developing gallstone disease in RA women compared with general population women was 2,3 (95% CI: 1.3–4.1). A significantly higher HDL3-c subfraction and higher apoA-I/HDL and HDL3-c/TC ratios were observed in patients with gallstone disease. Conclusion Women with rheumatoid arthritis may have a predisposition to gallstones that can manifest in middle or older age compared with women in the general population. This situation could be related to chronic inflammation and HDL metabolism.
ISSN:1699-258X
2173-5743
DOI:10.1016/j.reuma.2017.06.013