PACE trial authors continue to ignore their own null effect

Protocols and outcomes for the PACE trial were changed after the start of the trial. These changes made substantial differences, leading to exaggerated claims for the efficacy of cognitive behavior therapy and graded exercise therapy in myalgic encephalomyelitis/chronic fatigue syndrome. The small,...

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Bibliographic Details
Published in:Journal of health psychology 2017-08, Vol.22 (9), p.1134-1140
Main Author: Vink, Mark
Format: Article
Language:English
Subjects:
Chronic fatigue syndrome
Cognition & reasoning
Cognitive Behavioral Therapy
Dissent and Disputes
Efficacy
Encephalomyelitis
Exercise Therapy
Fatigue
Fatigue Syndrome, Chronic - psychology
Fatigue Syndrome, Chronic - therapy
Humans
Outcome Assessment (Health Care)
Randomized Controlled Trials as Topic
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Summary:Protocols and outcomes for the PACE trial were changed after the start of the trial. These changes made substantial differences, leading to exaggerated claims for the efficacy of cognitive behavior therapy and graded exercise therapy in myalgic encephalomyelitis/chronic fatigue syndrome. The small, self-reported improvements in subjective measures cannot be used to say the interventions are effective, particularly in light of the absence of objective improvement. Geraghty’s criticism of the trial was reasonable and supported by the evidence.
ISSN:1359-1053
1461-7277
DOI:10.1177/1359105317703785