Multiplex, quantitative cellular analysis in large tissue volumes with clearing-enhanced 3D microscopy (Cₑ3D)

Organ homeostasis, cellular differentiation, signal relay, and in situ function all depend on the spatial organization of cells in complex tissues. For this reason, comprehensive, high-resolution mapping of cell positioning, phenotypic identity, and functional state in the context of macroscale tiss...

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Bibliographic Details
Published in:Proceedings of the National Academy of Sciences - PNAS 2017-08, Vol.114 (35), p.E7321-E7330
Main Authors: Li, Weizhe, Germain, Ronald N., Gerner, Michael Y.
Format: Article
Language:English
Subjects:
Animals
Biological activity
Biological Sciences
Cell adhesion & migration
Clearing
Cytometry
Differentiation (biology)
Female
Fluorescence
Genotype & phenotype
High resolution
Histological Techniques - methods
Homeostasis
Imaging, Three-Dimensional - methods
Immune system
Immunology and Inflammation
Lymphoid tissue
Male
Mice
Mice, Transgenic
Microscopy
Microscopy, Confocal - methods
Multiplexing
PNAS Plus
Populations
Quantitative analysis
Signal quality
Spatial distribution
Studies
Tissue engineering
Tissues
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