Long-term disability and progression in spinal onset multiple sclerosis

• Published in: Acta neurologica Belgica 2018-06, Vol.118 (2), p.217-225
• Main Authors: Tiftikcioglu, Bedile Irem, Ilgezdi, Irem, Zorlu, Yasar, Sener, Ufuk, Tokucoglu, Figen
• Format: Article
• Language: English
• Subjects: Biomedical and Life Sciences; Biomedicine; Medicine/Public Health; Neurology; Neuroradiology; Neurosciences; Original Article
• ISSN: 0300-9009; 2240-2993
• DOI: 10.1007/s13760-017-0828-1

The aim of this study is to investigate the long-term effects of the initial spinal cord (SC) involvement in MS patients. In this retrospective, single-center study, 824 patients with definite MS were screened. A total of 348 patients were excluded for ambiguous documentation of the initial relapse, pediatric onset, diagnosis of primary progressive disease, irregular assessments or visits causing doubt on the onset of progression time, and clinical follow-up duration less than 12 months. Eventually, 476 MS patients were included. Data regarding the demographics, initial symptoms, the degree of recovery from the initial relapse, neuroimaging, cerebrospinal fluid analysis, long-term disability, and progression were collected from the medical registry. The mean duration of follow-up was 7.49 ± 5.30 years. The percentage of patients entering the progressive disease course was 23.3 in the whole group. A total of 157 patients (33.0%) had SC involvement during the first clinical relapse. These patients were significantly older at disease onset (31.69 ± 10.18 vs. 29.55 ± 9.49; p   =  0.028), had higher rates of progression (32.5 vs. 18.8%; p  = 0.001), and had higher disability scores in long-term follow-up (3.41 ± 2.19 vs. 2.62 ± 1.81; p