Low-dose computed tomography: A solution for in vivo medical imaging and accurate patient-specific 3D bone modeling?

The number of in vivo clinical biomedical experiments based on computed tomography is increasing. International radiation-protection bodies are promoting the use of low-dose computed tomography to reduce radiation absorption by the subject undergoing imaging. On the other hand no data exist in the l...

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Bibliographic Details
Published in:Clinical biomechanics (Bristol) 2006-11, Vol.21 (9), p.992-998
Main Authors: Sint Jan, Serge Van, Sobzack, Stéphane, Dugailly, Pierre-Michel, Feipel, Véronique, Lefèvre, Philippe, Lufimpadio, Jean-Louis, Salvia, Patrick, Viceconti, Marco, Rooze, Marcel
Format: Article
Language:English
Subjects:
bone
Bone and Bones - diagnostic imaging
Cadaver
Humans
Imaging, Three-Dimensional - methods
In Vitro Techniques
LDCT
Low-dose computed tomography
Male
Models, Biological
Radiation Dosage
Radiographic Image Interpretation, Computer-Assisted - methods
Reproducibility of Results
Sensitivity and Specificity
Tomography, X-Ray Computed - methods
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Summary:The number of in vivo clinical biomedical experiments based on computed tomography is increasing. International radiation-protection bodies are promoting the use of low-dose computed tomography to reduce radiation absorption by the subject undergoing imaging. On the other hand no data exist in the literature to quantify whether or not low-dose computed tomography would lead to a decrease of result quality when used for three-dimensional bone modeling and related measurements. This paper aimed at finding a consensus between minimal X-ray radiation of the subject, and satisfactory image data quality, especially for accurate three-dimensional bone modeling. Several standard computed tomography and low-dose computed tomography sequences were analyzed in three tests and statistically compared. Absence of significant difference between standard and low-dose computed sequences indicated that the low-dose setting would not produce less accurate three-dimensional models, while it decreased the effective X-ray dose up to 90% compared to standard settings. Low-dose computed tomography seems suitable for accurate three-dimensional bone modeling, while the related effective X-ray radiation is low. Such setting is therefore advised for any in vivo medical imaging aiming to collect bone data.
ISSN:0268-0033
1879-1271
DOI:10.1016/j.clinbiomech.2006.05.007