Ascorbic acid combats arsenic-induced oxidative stress in mice liver

Repeated injections of arsenic trioxide induced oxidative stress and hepatotoxicity in mice as revealed from elevated levels of glutamate oxaloacetate transaminases, glutamate pyruvate transaminases, acid and alkaline phosphatases, lipid peroxidation along with reduction of superoxide dismutase, cat...

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Bibliographic Details
Published in:Ecotoxicology and environmental safety 2009-02, Vol.72 (2), p.639-649
Main Authors: Banerjee, Pathikrit, Bhattacharyya, Soumya Sundar, Bhattacharjee, Nandini, Pathak, Surajit, Boujedaini, Naoual, Belon, Philippe, Khuda-Bukhsh, Anisur Rahman
Format: Article
Language:English
Subjects:
Animals
Antioxidant
Antioxidants - pharmacology
Arsenic - toxicity
Arsenic intoxication
Arsenic Poisoning - drug therapy
Arsenic Poisoning - prevention & control
Ascorbic Acid - pharmacology
Biomarkers
Biomarkers - analysis
Electron microscopy
Enzyme Activation - drug effects
Enzyme Activation - physiology
Liver
Liver - drug effects
Liver - metabolism
Mice
Micronucleus Tests
Microscopy, Electron
Oxidative stress
Oxidative Stress - drug effects
Oxidative Stress - physiology
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Summary:Repeated injections of arsenic trioxide induced oxidative stress and hepatotoxicity in mice as revealed from elevated levels of glutamate oxaloacetate transaminases, glutamate pyruvate transaminases, acid and alkaline phosphatases, lipid peroxidation along with reduction of superoxide dismutase, catalase, reduced glutathione content, glutathione reductase and succinate dehydrogenase activities. The present investigation was undertaken to test whether simultaneous feeding of Vitamin-C can combat hepatotoxicity in arsenic intoxicated mice. Hepatoprotective potential of Vitamin-C was indicated by its ability to restore GSH, SOD, CAT, AcP, AlkP and GRD levels towards near normal. Electron microscopic studies further supported the biochemical findings confirming the hepatoprotective potential of ascorbic acid. Besides, cytogenetical endpoints (chromosome aberrations, micronuclei, mitotic index and sperm head anomaly) were also analyzed. Administration of Vitamin-C alone did not show any sign of toxicity of its own. Based on the present findings, ascorbic acid appears to have protective effects against arsenic toxicity and oxidative stress.
ISSN:0147-6513
1090-2414
DOI:10.1016/j.ecoenv.2008.07.005