Amygdala or hippocampus inactivation after retrieval induces temporary memory deficit

The hypothesis that memory is stored through a single stage of consolidation that results in a stable and lasting long-term memory has been challenged by the proposition that reactivation of a memory induces reconsolidation of the memory. The reconsolidation hypothesis is supported by evidence that,...

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Bibliographic Details
Published in:Neurobiology of learning and memory 2006-09, Vol.86 (2), p.144-149
Main Authors: Prado-Alcalá, Roberto A., Díaz del Guante, Miguel A., Garín-Aguilar, María E., Díaz-Trujillo, Arnulfo, Quirarte, Gina L., McGaugh, James L.
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Action Potentials - physiology
Amnesia, Retrograde - chemically induced
Amygdala - drug effects
Amygdala - physiology
Animals
Avoidance Learning - drug effects
Avoidance Learning - physiology
Behavioral psychophysiology
Biological and medical sciences
Brain
Consolidation
Dose-Response Relationship, Drug
Fundamental and applied biological sciences. Psychology
Hippocampus - drug effects
Hippocampus - physiology
Inhibitory avoidance
Male
Memory
Microinjections
Neurology
Psychology. Psychoanalysis. Psychiatry
Psychology. Psychophysiology
Rat
Rats
Rats, Wistar
Reconsolidation
Retention (Psychology) - drug effects
Retention (Psychology) - physiology
Retrieval
Sodium Channel Blockers - administration & dosage
Tetrodotoxin
Tetrodotoxin - administration & dosage
Time Factors
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Summary:The hypothesis that memory is stored through a single stage of consolidation that results in a stable and lasting long-term memory has been challenged by the proposition that reactivation of a memory induces reconsolidation of the memory. The reconsolidation hypothesis is supported by evidence that, under some conditions, post-retrieval treatments affecting amygdala and hippocampus functioning impair subsequent retention performance. We now report that repeated retention testing attenuates the performance impairment induced by post-retrieval reversible inactivation of the amygdala and hippocampus of rats induced by tetrodotoxin. These findings challenge the reconsolidation hypothesis and suggest that the post-retrieval retention performance impairment is best explained as due to temporary retrieval failure.
ISSN:1074-7427
1095-9564
DOI:10.1016/j.nlm.2006.01.006