Symptom evaluation during the methacholine test: Does it add to the interpretation of the test results based on the PC20FEV1?

Purpose Conventionally, symptoms occurring during the methacholine test are not taken into account when interpreting the test results. We examined whether the evaluation of methacholine‐induced symptoms (MIS) added to the test interpretation based on the PC20FEV1 by assessing their prevalence, their...

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Bibliographic Details
Published in:The clinical respiratory journal 2018-04, Vol.12 (4), p.1536-1544
Main Authors: Bohadana, Abraham B., Wild, Pascal, Izbicki, Gabriel
Format: Article
Language:English
Subjects:
Administration, Inhalation
Adult
airway hyperresponsiveness
Asthma
Asthma - diagnosis
Asthma - epidemiology
Asthma - physiopathology
Bronchial Hyperreactivity - diagnosis
Bronchial Hyperreactivity - physiopathology
Bronchial Provocation Tests - methods
Bronchoconstriction - drug effects
Bronchoconstrictor Agents - administration & dosage
Female
Follow-Up Studies
Forced Expiratory Volume - drug effects
Humans
Incidence
Israel - epidemiology
Male
methacholine challenge test
Methacholine Chloride - administration & dosage
Surveys and Questionnaires
Symptom Assessment - methods
symptom perception
‘asthma‐like’ symptoms
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Summary:Purpose Conventionally, symptoms occurring during the methacholine test are not taken into account when interpreting the test results. We examined whether the evaluation of methacholine‐induced symptoms (MIS) added to the test interpretation based on the PC20FEV1 by assessing their prevalence, their similarity with symptoms justifying referral and their relationship with airway responsiveness. Methods Eighty‐two patients with suspected asthma completed a questionnaire of symptoms and underwent bronchial challenge with methacholine. Based on MIS and airway responsiveness (responders = PC20FEV1 
ISSN:1752-6981
1752-699X
DOI:10.1111/crj.12701