Increased local and decreased remote functional connectivity at EEG alpha and beta frequency bands in opioid-dependent patients

Although researchers now have a working knowledge of key brain structures involved in realization of actions of substance abuse and addiction, deeper understanding will require examination of network interactions between cortical neuronal assemblies and their subcortical tails in the effects of opio...

Full description

Saved in:
Bibliographic Details
Published in:Psychopharmacologia 2006-09, Vol.188 (1), p.42-52
Main Authors: FINGELKURTS, Andrew A, FINGELKURTS, Alexander A, KIVISAARI, Reetta, AUTTI, Taina, BORISOV, Sergei, PUUSKARI, Varpu, JOKELA, Olga, KÄHKÖNEN, Seppo
Format: Article
Language:English
Subjects:
Adult
Alpha Rhythm
Beta Rhythm
Biological and medical sciences
Brain
Brain Mapping
Case-Control Studies
Drug addiction
Female
Humans
Male
Medical imaging
Medical sciences
Middle Aged
Neocortex - physiopathology
Opioid-Related Disorders - physiopathology
Time Factors
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Although researchers now have a working knowledge of key brain structures involved in realization of actions of substance abuse and addiction, deeper understanding will require examination of network interactions between cortical neuronal assemblies and their subcortical tails in the effects of opioid dependence. Given that repeated exposure to opiates initiates a widespread reorganization of cortical regions, we predict that opioid dependence would result in a considerable reorganization of local and remote functional connectivity in the neocortex. We applied the novel operational architectonics approach that enables us to estimate two local and remote functional cortex connectivities by means of electroencephalogram structural synchrony measure. In 22 opioid-dependent patients, we found the evidence that brain functional connectivity was indeed disrupted by chronic opioid abuse (i.e., the local functional connectivity increased and remote functional connectivity decreased in opioid abusers). This significant difference between "opioid" and "control" populations was the same for alpha and beta frequency bands. Additionally, significant negative relations between duration (years) of daily opioid abuse and the number/strength of functional connections in the posterior section of the cortex were found.
ISSN:0033-3158
1432-2072
DOI:10.1007/s00213-006-0474-4