Longitudinal study of a NoGo-P3 event-related potential component following mild traumatic brain injury in adults

• Published in: Annals of physical and rehabilitation medicine 2018-01, Vol.61 (1), p.18-26
• Main Authors: Candrian, Gian, Müller, Andreas, Dall’Acqua, Patrizia, Kompatsiari, Kyveli, Baschera, Gian-Marco, Mica, Ladislav, Simmen, Hans-Peter, Glaab, Richard, Fandino, Javier, Schwendinger, Markus, Meier, Christoph, Ulbrich, Erika Jasmin, Johannes, Sönke
• Format: Article
• Language: English
• Subjects: Event-related potentials; Independent component analysis; Longitudinal; Mild traumatic brain injury
• ISSN: 1877-0657; 1877-0665
• DOI: 10.1016/j.rehab.2017.07.246

Event-related potentials have repeatedly revealed electrophysiological markers of cognitive dysfunction associated with Mild Traumatic Brain Injury (MTBI) and may represent a sensitive tool to guide cognitive rehabilitative interventions. We previously found patients with symptomatic MTBI characterized by smaller P300 (or P3) wave amplitudes in a NoGo-P3 subcomponent in the acute phase of the injury. The goal of this longitudinal study was to investigate whether this early NoGo-P3 subcomponent differs over time in symptomatic MTBI patients and healthy controls. We included adults with a diagnosis of MTBI and individually matched healthy controls tested at 1 week, 3 months, and 1 year after the MTBI. Symptoms were assessed by the Rivermead Post-Concussion Symptoms Questionnaire. NoGo-P3 was collected by using a cued Go/NoGo task and the relevant subcomponent was extracted by independent component analysis. Among 53 adults with a diagnosis of MTBI and 53 controls, we included 35 with symptomatic MTBI and 35 matched healthy controls (18 females each group; mean age 34.06±13.15 and 34.26±12.98 years). Amplitudes for the early NoGo-P3 subcomponent were lower for symptomatic MTBI patients than controls (P