DNA methylation patterns at sweet taste transducing genes are associated with BMI and carbohydrate intake in an adult population

Individual differences in taste perception may influence appetite, dietary intakes, and subsequently, disease risk. Correlations of DNA methylation patterns at taste transducing genes with BMI and dietary intakes were studied. A nutriepigenomic analysis within the Methyl Epigenome Network Associatio...

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Bibliographic Details
Published in:Appetite 2018-01, Vol.120, p.230-239
Main Authors: Ramos-Lopez, O., Arpón, A., Riezu-Boj, J.I., Milagro, F.I., Mansego, M.L., Martinez, J.A., Abete, I., Crujeiras, A.B., Cuervo, M., Goni, L., Marti, A., Martinez-Gonzalez, M.A., Moreno-Aliaga, M.J., Navas-Carretero, S., San Cristobal, R., Santos, J.L., Zulet, M.A.
Format: Article
Language:English
Subjects:
Adult
Body Mass Index
Dietary Carbohydrates
Dietary intake
DNA Methylation - genetics
Eating - genetics
Female
Humans
Linear Models
Male
Methylation
Middle Aged
Obesity
Receptors, G-Protein-Coupled - genetics
Signal Transduction - genetics
Sweet taste
TAS1R2
Taste perception
Taste Perception - genetics
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Summary:Individual differences in taste perception may influence appetite, dietary intakes, and subsequently, disease risk. Correlations of DNA methylation patterns at taste transducing genes with BMI and dietary intakes were studied. A nutriepigenomic analysis within the Methyl Epigenome Network Association (MENA) project was conducted in 474 adults. DNA methylation in peripheral white blood cells was analyzed by a microarray approach. KEGG pathway analyses were performed concerning the characterization and discrimination of genes involved in the taste transduction pathway. Adjusted FDR values (p 
ISSN:0195-6663
1095-8304
DOI:10.1016/j.appet.2017.09.004